Ferroptosis, as a new type of programmed cell death characterized by iron dependence and lipid peroxidation, is an important target for inhibiting proliferation, metastasis and reversing drug resistance of urinary tumors. Traditional Chinese medicine (TCM) and its active compounds have unique advantages in the field of regulating ferroptosis due to their multi-target and low toxicity, mainly reflected in the synergistic intervention of key pathways of ferroptosis. Studies have shown that TCM plays an anti-tumor role by targeting the three classical pathways of regulating iron homeostasis, promoting lipid peroxidation and inhibiting the antioxidant defense system with glutathione peroxidase 4 as the core, promoting iron overload in urinary tumor cells and destroying the redox balance to induce ferroptosis. This article aims to systematically review the mechanism of TCM regulating ferroptosis in prevention and treatment of urinary tract tumors, in order to provide reference for its more in-depth molecular mechanisms research and wider clinical application.

traditional Chinese medicine  /  flavonoids  /  alkaloids  /  terpenoids  /  artemisinin  /  urinary tumors  /  prostate cancer  /  bladder cancer  /  kidney cancer  /  ferroptosis  /  signal pathways