Based on Wuyun Liuqi (five movements and six qi) theory recorded in Huangdi Neijing (Yellow Emperor’s Inner Canon) and the Qiantang Medical School’s qi-transformation materia medica thought of “observing manifestations to differentiate qi and inspecting quality according to growth season”, this study integrates the “Sanyou” theory of genuine regional medicinal materials (Dao-di herbs) to propose a novel concept of “Yunqi Spatiotemporal Materia Medica”, constructing an integrated framework of “spatiotemporal qi-transformation-macroscopic properties-quality evaluation”. Taking Lurong (Cervi Cornu Pantotrichum), a genuine regional medicinal material (Dao-di herb) from Northeast China, as a typical example, systematic correspondences between its five stages of generation, growth, transformation, convergence, and storage and the governing periods of the six qi were established: antler casting and bud sprouting correspond to “generative transformation” of Jueyin wind-wood; the rapid growth period aligns with the “luxuriant transformation” of Shaoyang minister fire, during which amino acid and growth factor contents reach their peaks; The osteogenic transition responds to the pivot of the “moistening transformation” of Taiyin damp-earth; complete ossification manifests the astringency of “hardening transformation” of Yangming dryness-metal; And winter dormancy accords with the latency of the “storing transformation” of Taiyang cold-water. The proposal of Yunqi Spatiotemporal Materia Medica aims to refine the spatiotemporally integrated quality evaluation system for medicinal materials, thereby facilitating the regional planning of genuine medicinal materials, season-appropriate harvesting, and dynamic quality control.

Wuyun Liuqi (five movements and six qi)  /  Yunqi Spatiotemporal Materia Medica  /  genuine regional medicinal materials (Dao-di herbs)  /  quality evaluation  /  Cervi Cornu Pantotrichum