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Study on optimization of processing technology and antidiarrheal efficacy of Crataegi Fructus Charcoal based on thermal analysis-electronic sensory technology
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Chinese Traditional and Herbal Drugs | 2026, 57(17) : 6743 - 6754
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Chinese Traditional and Herbal Drugs | 2026, 57(17): 6743-6754
Study on optimization of processing technology and antidiarrheal efficacy of Crataegi Fructus Charcoal based on thermal analysis-electronic sensory technology
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SUN Lin1,2,3,4, WEI Bingbin1, WANG Ying1, LIU Yingying1, MENG Xianglong1,2,3,4, YAN Xiaoning1,2,3,4, ZHANG Shuosheng1,2,3,4
Affiliations
    1 School of Chinese Materia Medicine and Food Engineering, Shanxi University of Chinese Medicine, Jinzhong 030619, China;
    2 Shanxi Provincial Key Laboratory of Chinese Medicine Processing, Jinzhong 030619, China;
    3 Chinese Medicine Processing Technology Inheritance Base (Shanxi University of Chinese Medicine), Jinzhong 030619, China;
    4 Heritage and Innovation Laboratory for Chinese Medicinal Materials Processing, Jinzhong 030619, China
doi: 10.7501/j.issn.0253-2670.2026.17.008
Outline
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Objective To optimize the processing technology of Shanzhatan (Crataegi Fructus Charcoal, CFC), evaluate it objectively by electronic sensory technology, and verify its antidiarrheal efficacy. Methods TG-DTG thermal analysis was used to investigate the pyrolysis behavior of total flavonoids, total organic acids, polysaccharides, and tannins in hawthorn, and to determine the processing temperature range. With tannin content as the key index, frying temperature and time were selected as process variables, and the technology was optimized through single-factor experiments combined with central combination design-response surface methodology (CCD-RSM). An electronic eye, electronic nose, and electronic tongue were applied to quantitatively evaluate the color, odor, and taste profiles of hawthorn before and after processing. A Fanxieye (Sennae Folium)-induced mouse diarrhea model was established to validate the antidiarrheal efficacy of the CFC prepared under the optimized process, with body weight change, diarrhea index, gastrointestinal hormone (gastrin, VIP) levels, small intestinal propulsion rate, and gastric residual rate as indicators. Results Thermal analysis indicated that the optimal processing temperature range was 307.4—332.0 ℃. The optimal parameters were frying temperature 311 ℃ and frying time 3.64 min (218 s). Electronic sensory analysis showed obvious differences in lightness (L), red-green degree (a), yellow-blue degree (b), total color difference (Eab), odor, and taste characteristics between raw and processed hawthorn. The e-nose response signals were positively correlated with e-eye chromaticity values. Compared with the model group, the CFC group attenuated the trend of body weight loss (P < 0.05), reduced diarrhea index (P < 0.05), reversed serum gastrin and vasoactive intestinal peptide (VIP) levels (P < 0.05), increased gastric residual rate (P < 0.01), and a numerically lower but statistically non-significant small intestinal propulsion rate. Conclusion The processing technology was optimized by thermal analysis and response surface methodology. Electronic sensory technology enabled objective quantification of sensory attributes, and pharmacodynamic validation further confirmed the rationality of the process. This study provides a methodological reference for parameterizing fire intensity and duration in the preparation process of hawthorn charcoal and the construction of its quality standards.
Crataegi Fructus Charcoal  /  thermal analysis  /  electronic sensory technology  /  process optimization  /  antidiarrheal efficacy
孙琳, 魏冰斌, 王瑛, 刘莹莹, 孟祥龙, 闫晓宁, 张朔生. 基于热分析-电子感官技术的山楂炭炮制工艺优化与止泻作用研究. 中草药, 2026 , 57 (17) : 6743 -6754 . DOI: 10.7501/j.issn.0253-2670.2026.17.008
SUN Lin, WEI Bingbin, WANG Ying, LIU Yingying, MENG Xianglong, YAN Xiaoning, ZHANG Shuosheng. Study on optimization of processing technology and antidiarrheal efficacy of Crataegi Fructus Charcoal based on thermal analysis-electronic sensory technology[J]. Chinese Traditional and Herbal Drugs, 2026 , 57 (17) : 6743 -6754 . DOI: 10.7501/j.issn.0253-2670.2026.17.008
Year 2026 volume 57 Issue 17
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doi: 10.7501/j.issn.0253-2670.2026.17.008
  • Receive Date:2026-04-15
  • Online Date:2026-10-29
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  • Received:2026-04-15
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表12种不同金属材料的力学参数
科
Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)
属
Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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