The blood-brain barrier is the core bottleneck for drug delivery to the central nervous system. Bingpian (Borneolum Syntheticum), as a traditional “guide” drug, can reversibly modulate blood-brain barrier permeability, thereby providing a unique natural efficacy-enhancing tool for brain-targeted delivery. Therefore, integrating Borneolum Syntheticum into the construction strategies of modern drug delivery systems is a powerful approach to achieve synergistic enhancement. By retrieving relevant literature on Borneolum Syntheticum-mediated brain-targeted drug delivery systems published since 2018 from CNKI and PubMed databases, focusing on the construction strategies of such drug delivery systems, this study summarized them into three categories: physical loading, chemical conjugation, and biological fusion. The design principles, carrier characteristics, and representative systems of each strategy are elaborated in detail. The influence rules between construction strategies and key properties of drug delivery systems, including stability, release capacity, blood-brain barrier crossing ability, and delivery efficacy, are deeply analyzed. Finally, the core decision-making principle of “treatment needs-strategy matching-process evaluation” is distilled, providing scientific basis and strategic references for the design, performance optimization, and clinical translation of such systems.

Borneolum Syntheticum  /  nervous system diseases  /  drug delivery systems  /  blood-brain barrier  /  construction strategies