Yupingfeng Powder (玉屏风散) was first recorded in Jiu Yuan Fang of the Southern Song Dynasty. It is composed of three herbs—Huangqi (Astragali Radix), Baizhu (Atractylodis Macrocephalae Rhizoma), and Fangfeng (Saposhnikoviae Radix)—and possesses the therapeutic effects of tonifying qi, consolidating the exterior, and arresting sweating. Existing reviews have primarily focused on its chemical constituents, pharmacological activities, or therapeutic progress in a single disease, whereas a systematic integration of the tripartite relationship among “clinical evidence-mechanism of action-material basis” remains insufficient. From a “multi-component, multi-target, multi-pathway” perspective, this article synthesizes the common regulatory networks of Yupingfeng Powder across different diseases, elucidates the scientific basis of its principle of “treating different diseases with the same method,” and proposes concrete research pathways across four dimensions: evidence-based validation, clinical therapeutic patterns, bioactive substances, and mechanisms of action. By constructing a four-in-one research framework, this review aims to advance the precise clinical application and in-depth development of Yupingfeng Powder.

Yupingfeng Powder  /  immunomodulation  /  respiratory diseases  /  Astragali Radix  /  Astragalus polysaccharides