Objective To investigate the chemical constituents of Tibetan medicine Ligularia virgaurea. Methods The compounds were isolated and purified by silica gel column chromatography, Sephadex LH-20, ODS reversed-phase column chromatography and semi-preparative HPLC, and the structures were identified by spectral data (NMR and MS). Results A total of 19 compounds were isolated and identified as follows 1-[(1S,3aR,4R,7S,7aS)-4-hydroxy-4-hydroxymethyl-7-propan-2-yl-1,2,3,3a,5,6,7,7a-octahydroinden-1-yl]ethanone (1), 10α-hydroxy-1-oxoeremophila-7(11),8(9)-dien-12,8-olide (2), 6α,10α-dihydroxy-1-oxoeremophila-7(11),8(9)-dien-12,8-olide (3), 3-hydroxycacalolide (4), 6β-acetoxy-9-oxo-10αH-furanoeremophilane (5), pinoresinol (6), medioresinol (7), syringaresinol (8), p-hydroxybenzoic acid (9), methyl 3,4-dihydroxybenzoate (10), syringic acid (11), 3,4,5-trimethoxybenzoic acid (12), dimethy phthalate (13), syringin (14)、lupeol (15), obtusifoliol (16), ethyl linoleate (17), 15-vaccenic acid (18), 10-eicosenoic acid (19). Conclusion Compound 1 is a new compound, designated 14-hydroxy-oplopanone. Compounds 5—14, 16—19 are isolated from L. virgaurea for the first time.

Tibetan medicine  /  Ligularia virgaurea (Maxim.) Mattf.  /  14-hydroxy-oplopanone  /  pinoresinol  /  medioresinol  /  syringin  /  15-vaccenic acid