Objective To establish the pressing process of the Fujv decoction pieces of Daqingye (Isatidis Folium, IF), and determine the optimal process parameters. Methods The contents of indirubin, isovitexin and tryptanthrin in IF were determined by HPLC. The paste yield was determined by hot maceration. The analytic hierarchy process (AHP)-entropy weight method was used to determine the weight coefficients of each index and calculate the comprehensive score. Pressure, compression time, drying temperature and drying time were investigated as single factors. The AHP-entropy weight method combined with the Box-Behnken design-response surface methodoly (BBD-RSM) was used to optimize the pressing process of the decoction pieces of the Fujv decoction pieces of IF. Results The optimal parameters of the initial pressing process of the decoction pieces of the Fujv decoction pieces are as follows: After moistening, the medicinal materials were cut into 5—7 mm pieces, pressed at 4 MPa for 60 s, and baked at 60 ℃ for 4 h. Under these conditions, the overall desirability (OD) value of the validation tests was 94.12%, which is close to the predicted OD value of 93.30%. Conclusion The compression process for IF Fujv decoction pieces is practically feasible, providing a reference for the development and utilization of such pieces.

Isatidis Folium  /  Fujv decoction pieces  /  Box-Behnken design-response surface methodoloy  /  AHP-entropy weight method  /  pressing process  /  indirubin  /  isovitexin  /  tryptanthrin