Lipidomics enables the systematic analysis of the composition, functions, and metabolic networks of lipid molecules in organisms. Its holistic analytical characteristics are highly consistent with the “multi-component, multi-target, and holistic regulation” mode of traditional Chinese medicine (TCM), providing key technical support for elucidating mechanisms of TCM in treating liver diseases. This article systematically reviews the research achievements in the field of lipidomics applied to TCM for liver disease treatment over the past five years. It focuses on analyzing the regulatory effects of TCM on various liver disease-related metabolic pathways and key targets, organizes the lipid regulation mechanisms of different TCM therapeutic approaches, and summarizes the application value of lipidomics in analyzing the efficacy-related substances of TCM, validating the processing of Chinese medicinal materials, and elucidating the mechanisms of TCM formulation compatibility. The study aims to provide theoretical references and practical insights for enhancing research on mechanism of TCM in treating liver diseases through lipidomics, promoting clinical precision diagnosis and treatment, and advancing modernization of TCM theory.

lipidomics  /  liver disease  /  traditional Chinese medicine  /  traditional Chinese medicine treatment methods  /  metabolic pathways  /  action targets