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To investigate the flow field characteristics of peritoneal fluid flowing in the cavity between the liver and the inner wall of the diaphragm peritoneum in patients with ovarian cancer and the effects on deformation of the liver and diaphragm peritoneum.
A bidirectional fluid-structure interaction (FSI) analysis was conducted using COMSOL to investigate the interaction between the peritoneal fluid and the liver and diaphragm peritoneum under varying inlet velocities and viscosity functions.
The accuracy of the simulation was validated by comparing the simulation results with the contour lines of the CT scans, and the displacement error between the two was smaller than 5%. When the inlet velocity of the abdominal fluid increased from 0.1 m/s to 0.15 m/s, convex deformation of the diaphragm peritoneum increased by 193.3 μm, and concave deformation decreased by 304.1 μm. Meanwhile, the increase of the inlet velocity made the viscosity near the wall of deformed area increased, which improved the probability of the metastatic implantation of the cancer cells. The higher the viscosity in the main body region of the viscosity function, the larger convex deformation of the diaphragm peritoneum; the larger the linear fitting value in the tail, the smaller the concave deformation. The viscosity of the concave deformation area near the outlet of the right lobe was much larger than that of other areas, and cancer cells were more likely to metastasise in this area.
This study elucidates the relationship between peritoneal fluid flow and solid deformation, predicting the regions prone to cancer cell metastasis and implantation under various conditions. The findings provide a theoretical foundation for studying the motion of cancer cells within the flow field.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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