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To design and verify an implantable dialysis port that enables the central venous catheter to no longer be placed on the body surface, and to study the effect of the central venous catheter's structural design on its performance.
The feasibility of the dialysis port was verified by flow and pressure experiments. Four representative catheter structures were analyzed by finite element method. The recirculation rate, flow rate-pressure ratio and proportion of indwelling particles were recorded, and performance differences were analyzed. An experimental platform was built to verify the simulation conclusion, and the fluid flow direction of the arteriovenous cavity was quantified by the salinity measurement method.
The dialysis port could reach the flow requirement of 300 mL/min under the 45 kPa pressure. The recirculation rate of the measured central venous catheter was between 10.7% and 23.5%, and the residual value of heparin was between 2.3% and 2.8%. The performance of the catheter with bundle mouth, positive position and side hole structure was better.
The implantable dialysis port can potentially cooperate with central venous catheters to establish a new vascular access approach. The structure of the central venous catheter should adopt the design of bundle mouth, positive position and side hole, which has better recirculation rate and heparin locking performance with low flow rate-pressure ratio. This study provides a theoretical and experimental basis for structural design and clinical selection of the central venous catheter.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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