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Research Progress of Microfluidic Extracorporeal Membrane Oxygenator
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Yi WEI1, Jinglong ZHANG2, Jincheng LIU2, Yonghui QIAO1, 2, 3, 4, 5
Journal of Medical Biomechanics | 2025, 40(5) : 1343 - 1353
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Journal of Medical Biomechanics | 2025, 40(5): 1343-1353
• Review Articles •
Research Progress of Microfluidic Extracorporeal Membrane Oxygenator
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Yi WEI1, Jinglong ZHANG2, Jincheng LIU2, Yonghui QIAO1, 2, 3, 4, 5
Affiliations
  • 1.School of Power and Energy, Northwestern Polytechnical University, Xi'an 710129, China
  • 2.Department of Cardiovascular Surgery, the First Affiliated Hospital of Airforce Medical University, Xi'an 710032, China
  • 3.National Key Laboratory of Science and Technology on Advanced Light-duty Gas-turbine, Beijing 100190, China
  • 4.Advanced Power Research Institute of Northwestern Polytechnical University, Tianfu New District, Chengdu 610299, China
  • 5.State Key Laboratory of Clean Energy Utilization, Zhejiang University, Hangzhou 310027, China
Published: 2025-10-01 doi: 10.16156/j.1004-7220.2025.05.034
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A microfluidic extracorporeal membrane oxygenator is an advanced extracorporeal life support device designed using microfluidic technology, capable of providing oxygenation support to patients with severe respiratory failure and other pulmonary diseases via extracorporeal circulation. Compared to conventional extracorporeal membrane oxygenators, it features a more superior biomimetic design, demonstrating potentials for improved therapeutic outcomes and reduced complications. This review summarizes the research progress of microfluidic extracorporeal membrane oxygenators in terms of hemodynamics, membrane materials, biocompatibility, gas exchange efficiency, and structural design. It analyzes how factors such as blood channel design, material selection and surface modification techniques impact the performance of microfluidic extracorporeal membrane oxygenators, such as biomimetic flow paths minimizing shear stress and endothelial cell linings significantly reducing thrombosis. Finally, the limitations of microfluidic extracorporeal membrane oxygenators are discussed, along with prospects for future development. Innovations are still needed in enhancing biocompatibility, portability, manufacturability, and cost reduction for microfluidic extracorporeal membrane oxygenators.

extracorporeal membrane oxygenation (ECMO)  /  membrane oxygenator  /  microfluidics  /  hemodynamics  /  biocompatibility  /  gas exchange
Yi WEI, Jinglong ZHANG, Jincheng LIU, Yonghui QIAO. Research Progress of Microfluidic Extracorporeal Membrane Oxygenator[J]. Journal of Medical Biomechanics, 2025 , 40 (5) : 1343 -1353 . DOI: 10.16156/j.1004-7220.2025.05.034
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Article Info
doi: 10.16156/j.1004-7220.2025.05.034
  • Receive Date：2024-11-29
  • Online Date：2026-03-27
  • Published：2025-10-01
Article Data
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History
  • Received：2024-11-29
  • Revised：2025-01-21
Funding
Affiliations
    1.School of Power and Energy, Northwestern Polytechnical University, Xi'an 710129, China
    2.Department of Cardiovascular Surgery, the First Affiliated Hospital of Airforce Medical University, Xi'an 710032, China
    3.National Key Laboratory of Science and Technology on Advanced Light-duty Gas-turbine, Beijing 100190, China
    4.Advanced Power Research Institute of Northwestern Polytechnical University, Tianfu New District, Chengdu 610299, China
    5.State Key Laboratory of Clean Energy Utilization, Zhejiang University, Hangzhou 310027, China
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