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Effects of Early Postoperative Changes in Graft Viscoelasticity on Stress Distributions Within the Knee Joint Following Anterior Cruciate Ligament Reconstruction
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Zizhan LIAN1, Bin SUN2, Shanjiang YU2, Yichen YAN1, Qinqin YANG1, Bin YANG2, Jie YAO1
Journal of Medical Biomechanics | 2025, 40(5) : 1129 - 1135
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Journal of Medical Biomechanics | 2025, 40(5): 1129-1135
Original Articles
Effects of Early Postoperative Changes in Graft Viscoelasticity on Stress Distributions Within the Knee Joint Following Anterior Cruciate Ligament Reconstruction
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Zizhan LIAN1, Bin SUN2, Shanjiang YU2, Yichen YAN1, Qinqin YANG1, Bin YANG2, Jie YAO1
Affiliations
  • 1.Key Laboratory of Biomechanics and Mechanobiology (Beihang University), Ministry of Education; Key Laboratory of Innovation and Transformation of Advanced Medical Devices, Ministry of Industry and Information Technology; National Medical Innovation Platform for Industry-Education Integration in Advanced Medical Devices (Interdiscipline of Medicine and Engineering), School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China
  • 2.Department of Orthopedics, Peking University International Hospital, Beijing 102206, China
Published: 2025-10-01 doi: 10.16156/j.1004-7220.2025.05.006
Outline
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Objective

To investigate stress distributions of the knee joint at 0 and 15th day after anterior cruciate ligament reconstruction (ACLR) under a compressive force through the axis of the femoral shaft onto the proximal femur.

Methods

A three-dimensional (3D) finite element model of the human knee joint incorporating viscoelastic material properties was developed. The one-dimensional (1D) Prony series viscoelastic constitutive model parameters for articular cartilage, menisci, ligaments, and anterior cruciate ligament (ACL) grafts were determined by fitting experimental creep curves. The viscoelastic parameters of ACL grafts at 15th day after ACLR surgery were extrapolated. Finite element simulations were then performed to analyze the von Mises stress distributions in knee ligaments, ACL grafts, articular cartilage, and menisci under 1.5 kN vertical downward compressive load applied to the femur, with loading durations of 1 second and 600 seconds.

Results

At 15th day after ACLR surgery, the initial relaxation modulus and equilibrium modulus of human ACL grafts remained elevated compared to native ACL tissues, resulting in a significantly higher stress concentration within the grafts relative to healthy ACL. Despite the compromised mechanical properties of the grafts after ACLR surgery, the vertical downward compressive force applied to the femur under both short-term (1 s) and prolonged (600 s) loading durations, exhibited a minimal biomechanical impact on articular cartilage and meniscal structures.

Conclusions

Following ACLR, vertical compressive loads during weight-bearing rehabilitation exercises such as standing demonstrate minimal impact on articular cartilage and meniscus, while promoting fibrous regeneration of the graft. This renders such exercises a prudent early-stage rehabilitation strategy. Graft preparation requires balanced consideration of elastic and viscous properties, with grafts exhibiting higher relaxation modulus and viscosity coefficient than healthy ACL proving more effective in maintaining early postoperative knee stability.

anterior cruciate ligament reconstruction  /  graft  /  viscoelasticity  /  finite element analysis
Zizhan LIAN, Bin SUN, Shanjiang YU, Yichen YAN, Qinqin YANG, Bin YANG, Jie YAO. Effects of Early Postoperative Changes in Graft Viscoelasticity on Stress Distributions Within the Knee Joint Following Anterior Cruciate Ligament Reconstruction[J]. Journal of Medical Biomechanics, 2025 , 40 (5) : 1129 -1135 . DOI: 10.16156/j.1004-7220.2025.05.006
Year 2025 volume 40 Issue 5
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Article Info
doi: 10.16156/j.1004-7220.2025.05.006
  • Receive Date:2024-12-31
  • Online Date:2026-03-27
  • Published:2025-10-01
Article Data
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History
  • Received:2024-12-31
  • Revised:2025-02-06
Funding
Affiliations
    1.Key Laboratory of Biomechanics and Mechanobiology (Beihang University), Ministry of Education; Key Laboratory of Innovation and Transformation of Advanced Medical Devices, Ministry of Industry and Information Technology; National Medical Innovation Platform for Industry-Education Integration in Advanced Medical Devices (Interdiscipline of Medicine and Engineering), School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China
    2.Department of Orthopedics, Peking University International Hospital, Beijing 102206, China
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表12种不同金属材料的力学参数

Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)

Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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