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Polymyxin E is produced by fermentation of Bacillus polymyxa. It was usually purified by ion exchange. The extraction indexes of polymyxin E by D152 (weak acid cation resin) was studied, and the adsorption capacity, elution rate and yield of polymyxin E were obtained by matching D152 resin with the existing process equipment. The adsorption capacity of D152 resin can reach 6.8×106 U/mL (wet resin), and the total yield is ≥98.0% under the pH of polymyxin E filtrate in 6.0~7.0, the chromatotiter in 3.0×105 U/mL, the adsorption velocity of 1.0 BV/h and sulfuric acid elution velocity of 1.0~1.5 BV/h under the chromatotiter was adsorbed by three columns in series. After 6 months of continuous operation, D152 resin has stable performance.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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