Addressing the persistent challenge that general safety regulations are inadequate for metal mines employing specialized processes such as in-situ leaching, this study focuses on China's dominant in-situ leaching uranium mines and proposes a safety governance framework termed "three-layer decoupling and bidirectional integration". This methodology systematically develops China's Safety Regulations for In-situ Leaching Uranium Mines and three sets of mandatory safety assessment templates by decoupling complex risks, process stages, and heterogeneous standards, and integrating on-site requirements with regulatory provisions. The innovations are reflected in: the first cross-industry transformation and process adaptation of safety standards from multiple fields such as geological exploration and chemical engineering pipelines; the use of numerical simulation technology to verify and optimize threshold values for key clauses concerning drilling stability and leakage diffusion; and the complete reconstruction of the safety assessment paradigm, establishing a "standard-evaluation" closed-loop management and control system deeply integrated with the regulations. The outcomes have been implemented as mandatory industry standards. Application data indicate that mine safety compliance inspection efficiency has improved by approximately 50%. The systematic construction method and the integrated "regulation-assessment-application" formed in this research provide a replicable solution for the safety governance of other metal mines using similar leaching processes.