Uranium tailings produced by mining and smelting contain residual radioactivity, and the released radon gas is harmful to human. Covering control is an effective means to inhibit radon. In order to solve the problems of insufficient long-term stability and high cost of traditional covering materials, this study proposed multi-layer covering system based on alkali-activated solidification materials for uranium tailings, and carried out the trial in a tailings pond in the south of China. The selected sodium silicate (with a modulus of 2.0) as the alkali activator, mineral powder as the active material, and river sand as the fine aggregate, determined the optimal mix proportion as mineral powder : solid sodium silicate : uranium tailings (1.25-1.60 mm): river sand : water = 0.8 : 0.2 : 1.4 : 0.6 : 0.5 (mass ratio), with a compressive strength of 10.6 MPa for the solidified body at 28 days. With the alkali-activated solidified body of uranium tailings as the radon shielding layer, the test shows that the radon reduction efficiency of the 5 cm thick alkali-activated solidified body reaches 97.85 %. The multi-layer covering system constructed with the alkali-activated solidified body of tailings as the radon shielding layer consists of a protective layer, a vegetation layer, a radon shielding layer, a drainage layer and a barrier layer, which has functions such as corrosion resistance, seepage prevention, radon reduction, etc., and the radon excretion rate after covering is stable within 0.187-0.419 Bq/(m³·s), which meets the national standard. This system has excellent resistance to wind erosion, rainwater scouring and differential settlement and has good long-term stability. Economic analysis shows that the material cost of this system is only 75% of the same system at home and abroad, and the local of uranium tailings to achieve resource recycling has both environmental benefits and economic advantages, providing an efficient and feasible technical scheme for the decommissioning and treatment of uranium tailings pond.