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Research Advances in Pathogenesis and Prevention of Clostridium novyi Type B
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Ming WEI1, 2, Yanwei GUO3, Xiaoxia REN1, Yan FENG1, Meijun JIN1, Haoran ZHAO1, Liangquan ZHU1, Junping LI1, Wensheng YAO1, Yizhi ZHANG1, Ming ZOU2
Acta Veterinaria et Zootechnica Sinica | 2026, 57(3) : 1316 - 1323
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Acta Veterinaria et Zootechnica Sinica | 2026, 57(3): 1316-1323
• REVIEW •
Research Advances in Pathogenesis and Prevention of Clostridium novyi Type B
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Ming WEI1, 2, Yanwei GUO3, Xiaoxia REN1, Yan FENG1, Meijun JIN1, Haoran ZHAO1, Liangquan ZHU1, Junping LI1, Wensheng YAO1, Yizhi ZHANG1, Ming ZOU2
Affiliations
  • 1.China Institute of Veterinary Drug Control，Beijing 100081，China
  • 2.Qingdao Agricultural University，Qingdao 266109，China
  • 3.Liaocheng Academy of Agricultural Sciences，Liaocheng 252000，China
Published: 2026-03-23 doi: 10.11843/j.issn.0366-6964.2026.03.013
Outline
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Clostridium novyi is an opportunistic pathogen widely distributed in nature，primarily infects cattle and sheep，causing a range of acute diseases such as infectious necrotic hepatitis （black disease）， septicemia， and gas gangrene， which severely hindered the development of global livestock industries. This review systematically summarizes the pathogenic mechanisms and prevention and control techniques of Clostridium novyi type B， and conducts a comparative evaluation of the principles， advantages， and limitations of associated vaccines. The analysis aims to provide both theoretical foundations and methodological insights for advancing mechanistic studies and optimizing prevention practices against Clostridium novyi type B infections.

Clostridium novyi type B  /  Tcnα  /  infectious necrotic hepatitis  /  pathogenesis  /  vaccine research
魏铭, 郭延伟, 任小侠, 冯妍, 金美君, 赵浩然, 朱良全, 李俊平, 姚文生, 张一帜, 邹明. B型诺维梭菌致病机制与防治技术. 畜牧兽医学报, 2026 , 57 (3) : 1316 -1323 . DOI: 10.11843/j.issn.0366-6964.2026.03.013
Ming WEI, Yanwei GUO, Xiaoxia REN, Yan FENG, Meijun JIN, Haoran ZHAO, Liangquan ZHU, Junping LI, Wensheng YAO, Yizhi ZHANG, Ming ZOU. Research Advances in Pathogenesis and Prevention of Clostridium novyi Type B[J]. Acta Veterinaria et Zootechnica Sinica, 2026 , 57 (3) : 1316 -1323 . DOI: 10.11843/j.issn.0366-6964.2026.03.013
Appendix
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Year 2026 volume 57 Issue 3
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Article Info
doi: 10.11843/j.issn.0366-6964.2026.03.013
  • Receive Date：2025-05-08
  • Online Date：2026-09-16
  • Published：2026-03-23
Article Data
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History
  • Received：2025-05-08
Funding
Affiliations
    1.China Institute of Veterinary Drug Control，Beijing 100081，China
    2.Qingdao Agricultural University，Qingdao 266109，China
    3.Liaocheng Academy of Agricultural Sciences，Liaocheng 252000，China

Corresponding:

ZHANG Yizhi， E-mail：
ZOU Ming， E-mail：
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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