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Current Status and Application Prospects of Tetraploidy Compensation Technology in Domestic Animal Embryos
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Li MA1, Sirui MIN1, 2, Xinfeng LIU1, 2, Qiang CHEN1, 2
Acta Veterinaria et Zootechnica Sinica | 2026, 57(3) : 1205 - 1213
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Acta Veterinaria et Zootechnica Sinica | 2026, 57(3): 1205-1213
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Current Status and Application Prospects of Tetraploidy Compensation Technology in Domestic Animal Embryos
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Li MA1, Sirui MIN1, 2, Xinfeng LIU1, 2, Qiang CHEN1, 2
Affiliations
  • 1.College of Life Sciences,Ningxia University,Yinchuan 750021,China
  • 2.Key Laboratory of Protection and Utilization of Special Biological Resources in Western China of Ministry of Education,Ningxia University,Yinchuan 750021,China
Published: 2026-03-23 doi: 10.11843/j.issn.0366-6964.2026.03.004
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Tetraploid embryo technology is an important tool for livestock genetic breeding and biomedical research, and its application potential is becoming more and more prominent. In this paper, we systematically review the key technologies, bottlenecks and future development directions of tetraploid in vitro embryo production in livestock. It focuses on the induction methods (e.g., physical, chemical, and biological methods), optimization of in vitro culture systems, and factors affecting the developmental efficiency of tetraploid embryos of major livestock species, such as pigs, cows, and sheep. By comparing the developmental characteristics of tetraploid embryos from different species, we reveal the core limiting factors such as abnormal activation of the embryonic genome and defective placental development. Combined with the cutting-edge technologies of gene editing and embryo-like culture, the application of this echnology in the fields of efficient breeding, disease modeling and xenotransplantation is envisioned, with a view to providing theoretical references and technological guidance for related research.

livestock  /  tetraploid embryos  /  in vitro production  /  embryo technology  /  embryo development
马莉, 闵思蕊, 刘新峰, 陈强. 四倍体补偿技术在家畜胚胎中的研究现状与应用前景. 畜牧兽医学报, 2026 , 57 (3) : 1205 -1213 . DOI: 10.11843/j.issn.0366-6964.2026.03.004
Li MA, Sirui MIN, Xinfeng LIU, Qiang CHEN. Current Status and Application Prospects of Tetraploidy Compensation Technology in Domestic Animal Embryos[J]. Acta Veterinaria et Zootechnica Sinica, 2026 , 57 (3) : 1205 -1213 . DOI: 10.11843/j.issn.0366-6964.2026.03.004
Year 2026 volume 57 Issue 3
182
82
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doi: 10.11843/j.issn.0366-6964.2026.03.004
  • Receive Date:2025-08-13
  • Online Date:2026-09-16
  • Published:2026-03-23
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  • Received:2025-08-13
Funding
Affiliations
    1.College of Life Sciences,Ningxia University,Yinchuan 750021,China
    2.Key Laboratory of Protection and Utilization of Special Biological Resources in Western China of Ministry of Education,Ningxia University,Yinchuan 750021,China

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CHEN Qiang, E-mail:
LIU Xinfeng, E-mail:
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表12种不同金属材料的力学参数
科
Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)
属
Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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