Full
Outline
Bile acids， which are significant metabolites， are generated by the liver and conveyed to the intestine. Microorganisms in the intestine modify and process bile acids into secondary bile acids. Historically， it was believed that bile acids were engaged in the absorption and metabolism processes of lipids and fat-soluble vitamins. An increasing number of studies have shown that bile acids can act as multiple signaling metabolites， which are essential for maintaining bile acid homeostasis， enterohepatic circulation， metabolism， intestinal barrier integrity， and intestinal mucosal immune homeostasis by regulating bile acid-related receptors and interactions with the microbiota. Unique lymphocyte populations cooperate with each other to jointly maintain the stability of the intestinal immune system. Among these elements， the equilibrium between pro-inflammatory T helper 17 cells （TH17） and anti-inflammatory regulatory T cells （Treg） holds particular significance. It is of great importance in safeguarding the homeostasis of the intestinal immune system. This article reviews the complex relationship and latest research progress between bile acids， intestinal microorganisms and intestinal mucosal immunity from the following three aspects： the interaction between bile acids and intestinal microorganisms， bile acid-related receptors， and the balance between TH17/Treg cells， in order to provide a theoretical basis for revealing the physiological functions of bile acids and their application in animal production.
218
100
| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
关闭全屏
No. 86 Xueyuan South Road, Haidian District, Beijing
010-62662699(Operation and Technical Support)
qkjq@cast.org.cn
Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House
