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Identification of Molecular Markers Associated with Body Weight and Size Traits through Genome-Wide Association Study in Dabieshan Cattle
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Liu ZHANG1, 2, Qian LI2, Shuanping ZHAO2, Hai JIN2, Qinggang LI2, Huibin ZHANG2, Xinyi DU2, Sihua JIN3, Yong ZHU4, Keqin ZHAO5, Lei XU2, Shujuan WANG1
Acta Veterinaria et Zootechnica Sinica | 2026, 57(1) : 181 - 193
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Acta Veterinaria et Zootechnica Sinica | 2026, 57(1): 181-193
• ANIMAL GENETICS AND BREEDING •
Identification of Molecular Markers Associated with Body Weight and Size Traits through Genome-Wide Association Study in Dabieshan Cattle
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Liu ZHANG1, 2, Qian LI2, Shuanping ZHAO2, Hai JIN2, Qinggang LI2, Huibin ZHANG2, Xinyi DU2, Sihua JIN3, Yong ZHU4, Keqin ZHAO5, Lei XU2, Shujuan WANG1
Affiliations
  • 1.College of Animal Science，Anhui Science and Technology University，Chuzhou 233100，China
  • 2.Anhui Provincial Key Laboratory of Livestock and Poultry Product Safety，Institute of Animal Husbandry and Veterinary Medicine，Anhui Academy of Agricultural Sciences，Hefei 230031，China
  • 3.College of Animal Science and Technology，Anhui Agricultural University，Hefei 230036，China
  • 4.Taihu County Jiuhong Agricultural Comprehensive Development Co. ，Ltd. ，Anqing 246200，China
  • 5.Anhui Province Huoshan County Shuikousi Agricultural Co. ，Ltd. ，Lu'an 237200，China
Published: 2026-01-23 doi: 10.11843/j.issn.0366-6964.2026.01.016
Outline
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The objective of this study was to identify molecular marker loci and candidate genes associated with body weight and size traits in Dabieshan cattle， thereby elucidating their genetic mechanisms. A total of 515 healthy Dabieshan cattle aged between 30 and 36 months were selected， phenotypic measurements of eight traits were performed， including body weight， withers height， body slanting length， chest circumference，abdominal circumference， cannon bone circumference，hucklebone width， and hip width. Genotyping was performed using the Neogen 100K SNP chip， and a genome-wide association study （GWAS） was conducted using a mixed linear model （MLM）. The results revealed 44 single nucleotide polymorphisms （SNPs） loci significantly associated with body weight and size traits， which were annotated to 426 candidate genes. Among these， 6 candidate genes （WFIKKN2， MMP2， MATN1， PUM1， VKORC1， and VKORC1L1） related to muscle development， chondrogenesis， and bone metabolism were of particular interest. Functional enrichment analysis using Gene Ontology （GO） and Kyoto Encyclopedia of Genes and Genomes （KEGG） further indicated that the VKORC1 and VKORC1L1 genes are involved in key biological processes such as vitamin K metabolism， which warrants further investigation. In conclusion， the findings of this study provide clear molecular targets and valuable insights for the genetic improvement of the Dabieshan cattle.

Dabieshan cattle  /  SNP  /  body weight and size traits  /  whole-genome association study
张刘, 李倩, 赵拴平, 金海, 李庆岗, 章会斌, 杜欣怡, 金四华, 朱勇, 赵克勤, 徐磊, 王淑娟. 全基因组关联分析筛选大别山牛体重体尺性状相关分子标记. 畜牧兽医学报, 2026 , 57 (1) : 181 -193 . DOI: 10.11843/j.issn.0366-6964.2026.01.016
Liu ZHANG, Qian LI, Shuanping ZHAO, Hai JIN, Qinggang LI, Huibin ZHANG, Xinyi DU, Sihua JIN, Yong ZHU, Keqin ZHAO, Lei XU, Shujuan WANG. Identification of Molecular Markers Associated with Body Weight and Size Traits through Genome-Wide Association Study in Dabieshan Cattle[J]. Acta Veterinaria et Zootechnica Sinica, 2026 , 57 (1) : 181 -193 . DOI: 10.11843/j.issn.0366-6964.2026.01.016
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Year 2026 volume 57 Issue 1
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Article Info
doi: 10.11843/j.issn.0366-6964.2026.01.016
  • Receive Date：2025-05-14
  • Online Date：2026-09-16
  • Published：2026-01-23
Article Data
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History
  • Received：2025-05-14
Funding
Affiliations
    1.College of Animal Science，Anhui Science and Technology University，Chuzhou 233100，China
    2.Anhui Provincial Key Laboratory of Livestock and Poultry Product Safety，Institute of Animal Husbandry and Veterinary Medicine，Anhui Academy of Agricultural Sciences，Hefei 230031，China
    3.College of Animal Science and Technology，Anhui Agricultural University，Hefei 230036，China
    4.Taihu County Jiuhong Agricultural Comprehensive Development Co. ，Ltd. ，Anqing 246200，China
    5.Anhui Province Huoshan County Shuikousi Agricultural Co. ，Ltd. ，Lu'an 237200，China

Corresponding:

WANG Shujuan，E-mail：
XU Lei，E-mail：
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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