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Advances in Ferroptosis Pathogenesis and Phytochemical Modulation
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Jiayu CHEN1, 2, Hongchao LI1, 2, Wenwen WANG1, 2, Yuan WANG1, 2
Acta Veterinaria et Zootechnica Sinica | 2026, 57(3) : 1289 - 1298
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Acta Veterinaria et Zootechnica Sinica | 2026, 57(3): 1289-1298
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Advances in Ferroptosis Pathogenesis and Phytochemical Modulation
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Jiayu CHEN1, 2, Hongchao LI1, 2, Wenwen WANG1, 2, Yuan WANG1, 2
Affiliations
  • 1.College of Animal Science，Inner Mongolia Agricultural University，Hohhot 010018，China
  • 2.National Center of Technology Innovation for Dairy-Breeding and Production Research Center，Inner Mongolia Herbivorous Livestock Feed Engineering Technology Research Center，Integrated Research Platform of Smart Animal Husbandry at Universities of Inner Mongolia Autonomous Region，Key Laboratory of Smart Animal Husbandry at Universities of Inner Mongolia Automomous Region，Hohhot 010018，China
Published: 2026-03-23 doi: 10.11843/j.issn.0366-6964.2026.03.011
Outline
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Ferroptosis， a biologically significant form of regulated cell death， participates in the pathological processes of various metabolic diseases and toxicoses. The occurrence of ferroptosis adversely impacts animal production performance and may even lead to mortality， resulting in substantial economic losses for livestock farmers. Consequently， identifying effective functional additives to mitigate or block ferroptosis is of paramount importance. Plant extracts， defined as secondary metabolites isolated from plant tissues through standardized processes， typically contain bioactive compounds with well-documented pharmacological or regulatory functions， including alkaloids， flavonoids， polyphenols， and polysaccharides. These natural constituents exhibit regulatory effects on iron ion homeostasis， glutathione metabolism， and inhibition of lipid peroxidation， thereby counteracting ferroptosis. This review summarizes the pathogenic mechanisms of ferroptosis and the modulatory roles of plant extracts in its regulation， aiming to provide novel insights for the development of functional additives in animal husbandry.

plant extract  /  ferroptosis  /  antioxidant  /  animal production
陈佳瑜, 李宏超, 王文文, 王园. 铁死亡的致病机理与植物提取物调控的研究进展. 畜牧兽医学报, 2026 , 57 (3) : 1289 -1298 . DOI: 10.11843/j.issn.0366-6964.2026.03.011
Jiayu CHEN, Hongchao LI, Wenwen WANG, Yuan WANG. Advances in Ferroptosis Pathogenesis and Phytochemical Modulation[J]. Acta Veterinaria et Zootechnica Sinica, 2026 , 57 (3) : 1289 -1298 . DOI: 10.11843/j.issn.0366-6964.2026.03.011
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Year 2026 volume 57 Issue 3
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Article Info
doi: 10.11843/j.issn.0366-6964.2026.03.011
  • Receive Date：2025-03-21
  • Online Date：2026-09-16
  • Published：2026-03-23
Article Data
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History
  • Received：2025-03-21
Funding
Affiliations
    1.College of Animal Science，Inner Mongolia Agricultural University，Hohhot 010018，China
    2.National Center of Technology Innovation for Dairy-Breeding and Production Research Center，Inner Mongolia Herbivorous Livestock Feed Engineering Technology Research Center，Integrated Research Platform of Smart Animal Husbandry at Universities of Inner Mongolia Autonomous Region，Key Laboratory of Smart Animal Husbandry at Universities of Inner Mongolia Automomous Region，Hohhot 010018，China

Corresponding:

WANG Yuan， E-mail：
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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