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Outline
Animal mammary bioreactors utilize mammalian-specific lactoprotein gene promoters to direct the efficient and specific expression of exogenous genes in the animal mammary gland， ultimately obtaining protein expression products through the secretory function of the mammalian mammary gland. This article focuses on the application progress and research prospects of animal mammary bioreactors， providing theoretical reference value for future research and industrial development of animal mammary bioreactors. Through literature review and practical research， a brief overview is provided from the aspects of the principle， characteristics， target animal selection， application fields， challenges faced， and development prospects of animal mammary bioreactors. Different animal mammary bioreactors have their own advantages and disadvantages， and target animals can be reasonably selected according to actual needs and production practices. Compared with other traditional expression systems， mammary bioreactors are a novel expression mode with advantages such as high yield， easy purification， low cost， high biological activity， and high safety， and are widely used in improving animal milk quality， producing recombinant pharmaceutical proteins， making antibodies， synthesizing genetic engineering vaccines， and other fields. Although many influencing factors of mammary bioreactors are still unknown， there are some problems that urgently need to be solved， and challenges are also faced. However， with the rise of gene editing technologies such as CRISPR/Cas9， as long as technological innovation and research and development investment are continuously increased， their application prospects are very broad.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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