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The Role of IGF-1 in Mammalian Follicular Development
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Xuanjun LIU1, Yizhao LI1, Kaiyuan LIU1, Shanshan CHEN1, Haoyi FENG1, Xinjian LI1, Shenming ZENG2, Feng YANG1
Acta Veterinaria et Zootechnica Sinica | 2026, 57(3) : 1177 - 1186
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Acta Veterinaria et Zootechnica Sinica | 2026, 57(3): 1177-1186
• REVIEW •
The Role of IGF-1 in Mammalian Follicular Development
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Xuanjun LIU1, Yizhao LI1, Kaiyuan LIU1, Shanshan CHEN1, Haoyi FENG1, Xinjian LI1, Shenming ZENG2, Feng YANG1
Affiliations
  • 1.College of Animal Science and Technology，Henan Agricultural University，Zhengzhou 450046，China
  • 2.College of Animal Science and Technology，China Agricultural University，Beijing 100193，China
Published: 2026-03-23 doi: 10.11843/j.issn.0366-6964.2026.03.001
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During the estrous cycle of mammals， a large number of follicles are recruited. Typically， only one follicle is selected for dominance and ovulation in monotocous （single-offspring） species per cycle， while only a few follicles are selected for dominance in polytocous （multiple-offspring） species. The vast majority of the remaining follicles undergo atresia. In recent years， significant progress has been made in research focusing on follicular dominance selection， although the underlying mechanisms have not yet been fully elucidated. Insulin-like growth factor 1 （IGF-1） has been demonstrated to play a crucial role in follicular development. This review summarizes the roles and mechanisms of IGF-1 in mammalian follicular development， focusing on its involvement in dominant follicle selection， promotion of follicular growth and development， inhibition of granulosa cell apoptosis， and maintenance of normal reproductive performance in female mammals.

IGF-1  /  mammal  /  follicular development  /  hormonal regulation  /  endocrine
刘宣均, 李一兆, 刘开元, 陈姗姗, 冯浩义, 李新建, 曾申明, 杨峰. IGF-1在哺乳动物卵泡发育中的作用. 畜牧兽医学报, 2026 , 57 (3) : 1177 -1186 . DOI: 10.11843/j.issn.0366-6964.2026.03.001
Xuanjun LIU, Yizhao LI, Kaiyuan LIU, Shanshan CHEN, Haoyi FENG, Xinjian LI, Shenming ZENG, Feng YANG. The Role of IGF-1 in Mammalian Follicular Development[J]. Acta Veterinaria et Zootechnica Sinica, 2026 , 57 (3) : 1177 -1186 . DOI: 10.11843/j.issn.0366-6964.2026.03.001
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Year 2026 volume 57 Issue 3
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Article Info
doi: 10.11843/j.issn.0366-6964.2026.03.001
  • Receive Date：2025-06-27
  • Online Date：2026-09-16
  • Published：2026-03-23
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  • Received：2025-06-27
Funding
Affiliations
    1.College of Animal Science and Technology，Henan Agricultural University，Zhengzhou 450046，China
    2.College of Animal Science and Technology，China Agricultural University，Beijing 100193，China

Corresponding:

YANG Feng， E-mail：
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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