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Outline
This study aimed to analyze the medication law of the core medication for the treatment of dairy cow mastitis prescription. This study used Excel and GraphPad Prism software to analyze the basic information of the prescription for the treatment of dairy cow mastitis. IBM Spss Statistics 26.0， IBM Spss Modeler， and Cytoscape software were used for analyzing the performance and association of Chinese herbal medicines in the prescription. Data mining was conducted using association rules with IBM SPSS Statistics 26， IBM SPSS Modeler， and Cytoscape software to identify the core drugs. The clinical efficacy of the core drug dandelion was also validated. The results showed that a total of 239 prescriptions were included in the analysis， involving 185 different traditional Chinese medicines. The total frequency of drug use was 2 317. The core drugs identified were dandelion， angelica， licorice， honeysuckle and forsythia， with a frequency of ≥100 times. These drugs have different properties， including cold， warm， bitter， sweet， and pungent， and mainly belong to the liver， stomach， and lung meridians. The combination of dandelion-Zingiber officinale， honeysuckle drug pair had the highest confidence. Cluster analysis categorized the core drug into 7 groups， with dandelion being the most central drug in its use.Clinical efficacy tests demonstrated that the core drug， dandelion， significantly reduced the number of somatic cells in the milk of cows with subclinical mastitis and showed a good therapeutic effect on subclinical mastitis in dairy cows. In this study， dandelion was identified as the core drug for the treatment of dairy cow mastitis. This provides a reference for scientifically guiding the rational use of medication in the clinical treatment of dairy cow mastitis， as well as offering data support for the development of Chinese veterinary medicine for the prevention and treatment of dairy cow mastitis.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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