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Molecular Regulation Mechanisms of Mammary Gland Development and Lactation in Yak (Bos grunniens)
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Kun ZHANG1, 2, 3, Baoying LU4, Yougui FANG5, Hailong WANG6, Youhong XIN7, Qien YANG1, 2, 3
Acta Veterinaria et Zootechnica Sinica | 2026, 57(2) : 595 - 613
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Acta Veterinaria et Zootechnica Sinica | 2026, 57(2): 595-613
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Molecular Regulation Mechanisms of Mammary Gland Development and Lactation in Yak (Bos grunniens)
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Kun ZHANG1, 2, 3, Baoying LU4, Yougui FANG5, Hailong WANG6, Youhong XIN7, Qien YANG1, 2, 3
Affiliations
  • 1.Laboratory of Animal Reproduction and Functional Genomics,Northwest Institute of Plateau Biology,Chinese Academy of Sciences,Xining 810008,China
  • 2.University of Chinese Academy of Sciences,Beijing 100049,China
  • 3.Qinghai Provincial Key Laboratory of Animal Ecological Genomics,Xining 810008,China
  • 4.College of Veterinary Medicine,Southwest University,Chongqing 400715,China
  • 5.Maduo Agriculture and Animal Husbandry Service Center,Maduo 813500,China
  • 6.Xining Animal Disease Prevention and Control Center,Xining 810016,China
  • 7.Gangcha County Animal Husbandry and Veterinary Station of Qinghai Province,Gangcha 812399,China
Published: 2026-02-23 doi: 10.11843/j.issn.0366-6964.2026.02.003
Outline
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Yaks are well-adapted to the extreme environment of the Qinghai-Tibet Plateau, characterized by low temperatures, intense ultraviolet radiation, hypoxia, and nutritional stress, making them the dominant livestock species in high-altitude pastoral areas. Yak are multi-functional cattle breeds, possessing the performance of meat production, cashmere production, service use and milk production, however, their milk production performance has not undergone high-intensity breeding.Yaks have low milk yield but significantly higher milk fat, lactose and milk protein content.As the core organ for milk secretion, the development of yak mammary gland is regulated by complex network of genes, and the maintenance of its homeostasis and lactation is an intricate biological process of the organism, which relies on the coordinated functioning of multiple cells. With the development of omics technology and the deepening of functional genomics research,the core regulators of mammary gland development in human, mouse and common cow species have been analyzed, and the regulatory networks controlling key processes such as lactation and milk lipid secretion have been clarified. Although milk production is an economically important trait in yak, relatively few studies have been conducted on the regulatory network of mammary gland and lactation-regulating genes in yak.In this paper, the similarities and heterogeneity of yak mammary glands in terms of morphology, development, lactation mechanism, lactation performance and other aspects compared with mammary glands of other species were systematically summarized, and key scientific issues that need to be urgently addressed in yak-related aspects are presented with a view to providing important information for mammary gland biology research and identification of functional genes for milk production traits in yaks.

yak  /  mammary gland  /  development  /  lactation mechanism
张昆, 陆宝莹, 方有贵, 王海龙, 辛有宏, 杨其恩. 牦牛乳腺发育及其泌乳调控机制研究进展. 畜牧兽医学报, 2026 , 57 (2) : 595 -613 . DOI: 10.11843/j.issn.0366-6964.2026.02.003
Kun ZHANG, Baoying LU, Yougui FANG, Hailong WANG, Youhong XIN, Qien YANG. Molecular Regulation Mechanisms of Mammary Gland Development and Lactation in Yak (Bos grunniens)[J]. Acta Veterinaria et Zootechnica Sinica, 2026 , 57 (2) : 595 -613 . DOI: 10.11843/j.issn.0366-6964.2026.02.003
Year 2026 volume 57 Issue 2
237
111
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Article Info
doi: 10.11843/j.issn.0366-6964.2026.02.003
  • Receive Date:2025-07-18
  • Online Date:2026-09-16
  • Published:2026-02-23
Article Data
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History
  • Received:2025-07-18
Funding
Affiliations
    1.Laboratory of Animal Reproduction and Functional Genomics,Northwest Institute of Plateau Biology,Chinese Academy of Sciences,Xining 810008,China
    2.University of Chinese Academy of Sciences,Beijing 100049,China
    3.Qinghai Provincial Key Laboratory of Animal Ecological Genomics,Xining 810008,China
    4.College of Veterinary Medicine,Southwest University,Chongqing 400715,China
    5.Maduo Agriculture and Animal Husbandry Service Center,Maduo 813500,China
    6.Xining Animal Disease Prevention and Control Center,Xining 810016,China
    7.Gangcha County Animal Husbandry and Veterinary Station of Qinghai Province,Gangcha 812399,China

Corresponding:

YANG Qien, E-mail:
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表12种不同金属材料的力学参数
科
Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)
属
Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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