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Research Progress on Tryptophan Metabolites in Alleviating Intestinal Oxidative Stress
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Yunlong MENG1, 2, Yuankun DENG1, 2, Bi’e TAN1, 2, Jing WANG1, 2
Acta Veterinaria et Zootechnica Sinica | 2026, 57(1) : 46 - 57
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Acta Veterinaria et Zootechnica Sinica | 2026, 57(1): 46-57
• REVIEW •
Research Progress on Tryptophan Metabolites in Alleviating Intestinal Oxidative Stress
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Yunlong MENG1, 2, Yuankun DENG1, 2, Bi’e TAN1, 2, Jing WANG1, 2
Affiliations
  • 1.College of Animal Science and Technology，Hunan Agricultural University，Changsha 410128，China
  • 2.Yuelushan Laboratory，Changsha 410128，China
Published: 2026-01-23 doi: 10.11843/j.issn.0366-6964.2026.01.005
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The gastrointestinal tract is not only a place where nutrients digest， absorb and metabolize， but also serves as both a primary source and a major target of reactive oxygen species （ROS）. Intestinal health is a cornerstone of animal growth and a critical determinant of livestock production efficiency. Tryptophan， an essential amino acid， is metabolized by both host cells and gut microbiota into various bioactive compounds， such as indole， kynurenine and 5-hydroxytryptamine. These metabolites act as endogenous ligands to regulate intestinal oxidative stress and inflammatory damage. This review summarizes the host and microbial pathways of intestinal tryptophan metabolism， explores the physiological functions of tryptophan metabolites in modulating oxidative stress and tissue repair， and discusses the role of microbial tryptophan metabolism in potential nutritional interventions，including probiotics and nutritional supplements. These findings aim to inform research on nutritional strategies for managing gut health.

intestine  /  oxidative stress  /  tryptophan metabolism  /  intestinal microorganisms  /  nutritional regulation
孟云龙, 邓远坤, 谭碧娥, 王婧. 色氨酸代谢产物调控肠道氧化应激研究进展. 畜牧兽医学报, 2026 , 57 (1) : 46 -57 . DOI: 10.11843/j.issn.0366-6964.2026.01.005
Yunlong MENG, Yuankun DENG, Bi’e TAN, Jing WANG. Research Progress on Tryptophan Metabolites in Alleviating Intestinal Oxidative Stress[J]. Acta Veterinaria et Zootechnica Sinica, 2026 , 57 (1) : 46 -57 . DOI: 10.11843/j.issn.0366-6964.2026.01.005
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Year 2026 volume 57 Issue 1
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Article Info
doi: 10.11843/j.issn.0366-6964.2026.01.005
  • Receive Date：2024-12-24
  • Online Date：2026-09-16
  • Published：2026-01-23
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History
  • Received：2024-12-24
Funding
Affiliations
    1.College of Animal Science and Technology，Hunan Agricultural University，Changsha 410128，China
    2.Yuelushan Laboratory，Changsha 410128，China

Corresponding:

WANG Jing， E-mail：
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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