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Zinc-azithromycin is commonly utilized for the prevention and treatment of COVID-19. The effect of zinc-azithromycin on gut microbiota in vitro was explored to provide a theoretical basis for its clinical application. The effects of zinc-azithromycin on gut microbiota community and short chain fatty acids were inspected via in vitro fermentation, metagenomic sequencing, and gas chromatography. The results indicated that Zinc-azithromycin increased the relative abundance of Klebsiella, Rahnella, Pantoea, and significantly decreased the relative abundance of Megamonas and Bifidobacterium. Zinc-azithromycin also significantly altered the metabolism pathway, the abundance of antimicrobial resistance genes, and the content of short chain fatty acids of the gut microbiota, which might potentially have negative effects on human health.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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