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Outline
G protein-coupled receptors (GPCRs) in pathogenic fungi have become one of the critical targets for controlling pathogenic disease. In this study, 36 candidate GPCRs were identified from Penicillium expansum by bioinformatics approaches including three transmembrane prediction tools (DeepTMHMM, Phobius, and TOPCONS) and four GPCR prediction platforms (GPCRHMM, GPCRPipe, GPCR-Pen, and GPCRPred). The topological structure analysis, subcellular localization, and functional annotation demonstrated the reliability of the prediction strategy. Phylogenetic classification revealed that these candidate GPCRs were distributed across six distinct fungal GPCR classes, which are characterized by conserved domains such as fungal rhodopsin-like receptor families, pheromone mating factor STE2, pheromone A receptor STE3, and RTA1-like proteins. Physicochemical property analysis demonstrated that the candidate GPCRs predominantly exhibit neutral or alkaline proteins, with 44.44% classified as unstable proteins and 97.22% showing hydrophobic properties. These findings provide a critical theoretical foundation for elucidating the biological functions, signaling mechanisms, and pathogenic roles of GPCRs in P.expansum, and also highlighting potential targets for the development of novel antifungal molecules.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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