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Outline
D-Pantolactone serves as a pivotal chiral intermediate in the synthesis of D-pantothenic acid (vitamin B5) and its derivative compounds. Given the escalating global demand for D-pantolactone, the development of efficient and environmentally benign production routes has emerged as a critical research focus. Enzymatic synthesis of D-pantolactone stands out as a highly promising approach, distinguished by its green and eco-friendly attributes, and has become the predominant method in industrial production. This comprehensive review delves into the recent advancements in the enzymatic synthesis of D-pantolactone. It meticulously examines the enzymatic properties, expression, and directed evolution of D-pantolactone hydrolase under different experimental conditions. Additionally, it explores the latest progress in the asymmetric reduction of keto-pantolactone. By comparing the merits of various synthesis methods, this review offers valuable insights and guidance for the future design of production strategies for D-pantolactone and its derivatives.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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