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Research progress on the mechanisms of skin microecology regulating skin health
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Xiaoli XIE1, 2, Qingping WU1, 2, Ling CHEN2, 3, Ying LI2, 3, *, Yuwei WU4, *
Acta Microbiologica Sinica | 2026, 66(10) : 4733 - 4748
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Acta Microbiologica Sinica | 2026, 66(10): 4733-4748
• Review •
Research progress on the mechanisms of skin microecology regulating skin health
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Xiaoli XIE1, 2, Qingping WU1, 2, Ling CHEN2, 3, Ying LI2, 3, *, Yuwei WU4, *
Affiliations
  • 1.School of Food Science and Engineering, Shaanxi University of Science and Technology, Xi’an, Shaanxi, China
  • 2.State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Safety and Health, National Health Commission Science and Technology Innovation Platform for Nutrition and Safety of Microbial Foods, Key Laboratory of Big Data Technologies for Food Microbiological Safety, State Administration for Market Regulation, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou, Guangdong, China
  • 3.Food and Drug Laboratory, Guangdong Detection Center of Microbiology, Guangzhou, Guangdong, China
  • 4.Guangdong Kehuan Biotechnology Co. , Ltd. , Guangzhou, Guangdong, China
Published: 2026-10-04 doi: 10.13343/j.cnki.wsxb.20260196
Outline
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The skin microbiota refers to a complex ecosystem composed of diverse microorganisms that colonize the skin, which contributes to the maintenance of skin health through interactions with the host. Studies have demonstrated that an imbalanced skin microecology can cause various skin health problems through multiple pathways, such as the induction of DNA damage in skin cells and the promotion of pro-inflammatory factor secretion. In recent years, numerous studies have confirmed that probiotics play a significant role in improving skin health, with mechanisms including antioxidation, immunomodulation, and enhancement of skin barrier function. This review comprehensively summarized the composition of the skin microecology, its role in maintaining normal skin functions, and the research progress on the pathological mechanisms of skin problems induced by microecological imbalance. Based on this, this review systematically summarized the mechanisms and research progress of microecological therapy, particularly probiotics, in improving various skin health problems, especially skin cancer, skin inflammation and photoaging, aiming to provide a theoretical basis for the exploration of the mechanisms and application of probiotics in improving skin health.

skin health  /  microecology  /  cancer  /  inflammation  /  photoaging  /  probiotics
谢小利, 吴清平, 陈玲, 李滢, 吴毓薇. 皮肤微生态调控皮肤健康的作用机制研究进展. 微生物学报, 2026 , 66 (10) : 4733 -4748 . DOI: 10.13343/j.cnki.wsxb.20260196
Xiaoli XIE, Qingping WU, Ling CHEN, Ying LI, Yuwei WU. Research progress on the mechanisms of skin microecology regulating skin health[J]. Acta Microbiologica Sinica, 2026 , 66 (10) : 4733 -4748 . DOI: 10.13343/j.cnki.wsxb.20260196
Funding
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  • National Key Research and Development Program of China(2023YFF1104100)
  • Guangdong Provincial Key Research and Development Project(2022B1111070006)
  • Project of Guangdong Academy of Sciences(2022GDASZH-2022010101)
Appendix
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Year 2026 volume 66 Issue 10
177
78
Cite this Article
BibTeX
Article Info
doi: 10.13343/j.cnki.wsxb.20260196
  • Receive Date：2026-03-10
  • Online Date：2026-10-13
  • Published：2026-10-04
Article Data
Affiliations
History
  • Received：2026-03-10
  • Accepted：2026-04-25
Funding
National Key Research and Development Program of China(2023YFF1104100)
Guangdong Provincial Key Research and Development Project(2022B1111070006)
Project of Guangdong Academy of Sciences(2022GDASZH-2022010101)
Affiliations
    1.School of Food Science and Engineering, Shaanxi University of Science and Technology, Xi’an, Shaanxi, China
    2.State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Safety and Health, National Health Commission Science and Technology Innovation Platform for Nutrition and Safety of Microbial Foods, Key Laboratory of Big Data Technologies for Food Microbiological Safety, State Administration for Market Regulation, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou, Guangdong, China
    3.Food and Drug Laboratory, Guangdong Detection Center of Microbiology, Guangzhou, Guangdong, China
    4.Guangdong Kehuan Biotechnology Co. , Ltd. , Guangzhou, Guangdong, China

Corresponding:

*E-mail: LI Ying,
WU Yuwei,
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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