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Research progress in the regulatory effects of microbial-derived additives on cellular precision nutrition
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Kangqian LI1, 2, Qinghua YE2, Qingping WU2, Shuhong ZHANG2, Ying LI2, *, Yuwei WU3, *
Acta Microbiologica Sinica | 2026, 66(10) : 4749 - 4772
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Acta Microbiologica Sinica | 2026, 66(10): 4749-4772
• Review •
Research progress in the regulatory effects of microbial-derived additives on cellular precision nutrition
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Kangqian LI1, 2, Qinghua YE2, Qingping WU2, Shuhong ZHANG2, Ying LI2, *, Yuwei WU3, *
Affiliations
  • 1.College of Food Science, South China Agricultural University, Guangzhou, Guangdong, China
  • 2.State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Safety and Health, National Health Commission Science and Technology Innovation Platform for Nutrition and Safety of Microbial Food, Key Laboratory of Big Data Technologies for Food Microbiological Safety, State Administration for Market Regulation, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou, Guangdong, China
  • 3.Guangdong Huankai Biotechnology Co. , Ltd. , Zhaoqing, Guangdong, China
Published: 2026-10-04 doi: 10.13343/j.cnki.wsxb.20260205
Outline
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Conventional cell culture relies on serum, which has the problems of unclear composition, high cost, and contamination risks. Microbial-derived additives, with clear sources, low costs, safe components, and obvious pro-proliferative effects, have become an ideal alternative to serum in cell culture. To provide a basis for the development of new sources for the culture media of cells in agricultural production, this review first summarizes the role of microbial-derived additives in the research and development of serum-free media, and then elaborates on the application status of microbial-derived additives in cellular agriculture. On this basis, it probes into the mechanisms through which microbial-derived additives provide precision nutrition and promote cell proliferation. This review aims to provide technical support for the research and development of serum-free culture media, the establishment of cellular precision nutrition, and the sustainable development of cellular agriculture.

microbial-derived additives  /  cell culture  /  precision nutrition  /  cell proliferation  /  preparation process
李康倩, 叶青华, 吴清平, 张淑红, 李滢, 吴毓薇. 微生物衍生物在细胞精准营养中的调控作用研究进展. 微生物学报, 2026 , 66 (10) : 4749 -4772 . DOI: 10.13343/j.cnki.wsxb.20260205
Kangqian LI, Qinghua YE, Qingping WU, Shuhong ZHANG, Ying LI, Yuwei WU. Research progress in the regulatory effects of microbial-derived additives on cellular precision nutrition[J]. Acta Microbiologica Sinica, 2026 , 66 (10) : 4749 -4772 . DOI: 10.13343/j.cnki.wsxb.20260205
Funding
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  • National Key Research and Development Program of China(2024YFD2100904)
  • Guangdong Academy of Sciences Project(2022GDASZH-2022010101)
Appendix
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Year 2026 volume 66 Issue 10
189
85
Cite this Article
BibTeX
Article Info
doi: 10.13343/j.cnki.wsxb.20260205
  • Receive Date：2026-03-11
  • Online Date：2026-10-13
  • Published：2026-10-04
Article Data
Affiliations
History
  • Received：2026-03-11
  • Accepted：2026-04-25
Funding
National Key Research and Development Program of China(2024YFD2100904)
Guangdong Academy of Sciences Project(2022GDASZH-2022010101)
Affiliations
    1.College of Food Science, South China Agricultural University, Guangzhou, Guangdong, China
    2.State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Safety and Health, National Health Commission Science and Technology Innovation Platform for Nutrition and Safety of Microbial Food, Key Laboratory of Big Data Technologies for Food Microbiological Safety, State Administration for Market Regulation, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou, Guangdong, China
    3.Guangdong Huankai Biotechnology Co. , Ltd. , Zhaoqing, Guangdong, China

Corresponding:

*E-mail: LI Ying,
WU Yuwei,
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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