Home Journals Articles Updates About
CN
image
收藏切换
Prevention and treatment strategies targeting α-hemolysin (Hla) of Staphylococcus aureus
收藏切换
Tingting SUN1, 2, Xinyu WANG1, 2, Yang LIU1, 2, Yingying LI1, 2, Yuxing WANG1, 2, Fei XU1, 2, *
Acta Microbiologica Sinica | 2026, 66(10) : 4661 - 4678
Less
收藏切换
Acta Microbiologica Sinica | 2026, 66(10): 4661-4678
• Review •
Prevention and treatment strategies targeting α-hemolysin (Hla) of Staphylococcus aureus
Full
Tingting SUN1, 2, Xinyu WANG1, 2, Yang LIU1, 2, Yingying LI1, 2, Yuxing WANG1, 2, Fei XU1, 2, *
Affiliations
  • 1.National Feed Drug Reference Laboratories, Institute of Feed Research of Chinese Academy of Agricultural Sciences, Beijing, China
  • 2.Key Laboratory of Animal Antimicrobial Resistance Surveillance, Ministry of Agriculture and Rural Affairs, Beijing, China
Published: 2026-10-04 doi: 10.13343/j.cnki.wsxb.20260087
Outline
收藏切换

The emergence of superbugs with both high pathogenicity and high antimicrobial resistance poses a major challenge to public health. In Staphylococcus aureus, α-hemolysin (Hla) is a key virulence factor mediating infection and thus represents a crucial target for prevention and control. This review first summarized the structural characteristics of Hla in its monomeric crystalline form and heptameric pore assembly. It then systematically delineated the multi-layered and fine-tuned regulation of Hla expression, involving the hla gene locus, the Agr quorum-sensing system, the Sar protein family, the Staphylococcal accessory element regulator (SaeRS) two-component system, and other auxiliary regulators. The pathogenic mechanisms of Hla were further elaborated from the perspectives of both cellular effects and host receptors. Finally, this review summarized recent advances in prevention and treatment strategies targeting Hla, including vaccines, monoclonal antibodies, natural compounds, and nanoparticles, offering new insights and candidate approaches for the precise prevention of drug-resistant S. aureus infections.

Staphylococcus aureus  /  α-hemolysin (Hla)  /  mechanism of pathogenesis  /  prevention and treatment
孙婷婷, 王新宇, 刘洋, 李應英, 王宇星, 徐飞. 靶向金黄色葡萄球菌α-溶血素的防治策略. 微生物学报, 2026 , 66 (10) : 4661 -4678 . DOI: 10.13343/j.cnki.wsxb.20260087
Tingting SUN, Xinyu WANG, Yang LIU, Yingying LI, Yuxing WANG, Fei XU. Prevention and treatment strategies targeting α-hemolysin (Hla) of Staphylococcus aureus[J]. Acta Microbiologica Sinica, 2026 , 66 (10) : 4661 -4678 . DOI: 10.13343/j.cnki.wsxb.20260087
Funding
Less
  • National Key Research and Development Program of China(2023YFD1800902)
  • Agricultural Science and Technology Innovation Program(IFR-06)
  • Livestock Industry Technology Innovation Team in Beijing(BAIC05-2026)
Appendix
Less
Year 2026 volume 66 Issue 10
202
91
Cite this Article
BibTeX
Article Info
doi: 10.13343/j.cnki.wsxb.20260087
  • Receive Date：2026-01-28
  • Online Date：2026-10-13
  • Published：2026-10-04
Article Data
Affiliations
History
  • Received：2026-01-28
  • Accepted：2026-04-10
Funding
National Key Research and Development Program of China(2023YFD1800902)
Agricultural Science and Technology Innovation Program(IFR-06)
Livestock Industry Technology Innovation Team in Beijing(BAIC05-2026)
Affiliations
    1.National Feed Drug Reference Laboratories, Institute of Feed Research of Chinese Academy of Agricultural Sciences, Beijing, China
    2.Key Laboratory of Animal Antimicrobial Resistance Surveillance, Ministry of Agriculture and Rural Affairs, Beijing, China

Corresponding:

*E-mail:
References
Share
https://castjournals.cast.org.cn/joweb/wswxb/EN/10.13343/j.cnki.wsxb.20260087
Share to
QR

Scan QR to access full text

Cite this article
BibTeX
Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏
  • BibTeX
  • EndNote
  • RefWorks
  • TxT
Links
Articles
Latest Articles
Most Read
Collections
Updates
Events
News
Multimedia
About
About Us
Contact
No. 86 Xueyuan South Road, Haidian District, Beijing
100081
010-62662699(Operation and Technical Support)
qkjq@cast.org.cn

Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House