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Metabolic engineering of Methylorubrum extorquens AM1 and its applications in methanol-based chemical biosynthesis: a review
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Lin CUI1, 2, Xiaoyu WANG1, Yang HE3, Bin YAO1, Huiying LUO1, *, Xiaolu WANG1, *
Acta Microbiologica Sinica | 2026, 66(9) : 4520 - 4544
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Acta Microbiologica Sinica | 2026, 66(9): 4520-4544
• Review •
Metabolic engineering of Methylorubrum extorquens AM1 and its applications in methanol-based chemical biosynthesis: a review
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Lin CUI1, 2, Xiaoyu WANG1, Yang HE3, Bin YAO1, Huiying LUO1, *, Xiaolu WANG1, *
Affiliations
  • 1.State Key Laboratory of Animal Nutrition and Feeding, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, China
  • 2.Institute of Feed Research, Chinese Academy of Agricultural Sciences, Beijing, China
  • 3.Biotechnology Research Institute, Chinese Academy of Agricultural Sciences, Beijing, China
About Author:

These authors contributed equally to this work.

Published: 2026-09-04 doi: 10.13343/j.cnki.wsxb.20260545
Outline
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Methanol is regarded as an ideal non-food feedstock for biomanufacturing due to its abundant supply and low cost. Methylorubrum extorquens AM1 has become a prominent model chassis strain in this field, owing to its natural ability to utilize methanol. This review summarizes recent advances in methanol-based biomanufacturing viaM. extorquens AM1 cell factories. First, the methanol metabolic pathways and compatible synthetic biology tools available for this strain are discussed. Subsequently, we highlight recent achievements in the metabolic engineering of this strain for the production of recombinant proteins, biodegradable materials, organic acids, and terpenoids. Building on these findings, we outline the metabolic engineering strategies that have been employed to enhance the biosynthetic capacity of engineered strains. Finally, we discuss the current limitations in constructing and applying M. extorquens AM1 cell factories and propose future research directions. This review will serve as a valuable reference for the development of M. extorquens cell factories and for the industrial production of methanol-derived products.

Methylorubrum extorquens  /  metabolic engineering  /  methanol  /  chemicals production  /  biomanufacturing strategy
Lin CUI, Xiaoyu WANG, Yang HE, Bin YAO, Huiying LUO, Xiaolu WANG. Metabolic engineering of Methylorubrum extorquens AM1 and its applications in methanol-based chemical biosynthesis: a review[J]. Acta Microbiologica Sinica, 2026 , 66 (9) : 4520 -4544 . DOI: 10.13343/j.cnki.wsxb.20260545
Funding
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  • the National Natural Science Foundation of China(32573271)
  • the Central Public-interest Scientific Institution Basal Research Fund(Y2024QC08)
  • the Self-directed Research Projects of the State Key Laboratory of Animal Nutrition and Feeding(2004DA125184G2613)
Appendix
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Year 2026 volume 66 Issue 9
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Article Info
doi: 10.13343/j.cnki.wsxb.20260545
  • Receive Date：2026-07-09
  • Online Date：2026-09-09
  • Published：2026-09-04
Article Data
Affiliations
History
  • Received：2026-07-09
  • Accepted：2026-08-04
Funding
the National Natural Science Foundation of China(32573271)
the Central Public-interest Scientific Institution Basal Research Fund(Y2024QC08)
the Self-directed Research Projects of the State Key Laboratory of Animal Nutrition and Feeding(2004DA125184G2613)
Affiliations
    1.State Key Laboratory of Animal Nutrition and Feeding, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, China
    2.Institute of Feed Research, Chinese Academy of Agricultural Sciences, Beijing, China
    3.Biotechnology Research Institute, Chinese Academy of Agricultural Sciences, Beijing, China

Corresponding:

*E-mail: LUO Huiying,
WANG Xiaolu,
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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