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Metabolic engineering strategies and research advances in synthesis of chemicals through bioconversion of methanol
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Xiaomei SUN, Xin WANG, Kequan CHEN*
Acta Microbiologica Sinica | 2026, 66(9) : 4496 - 4519
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Acta Microbiologica Sinica | 2026, 66(9): 4496-4519
• Review •
Metabolic engineering strategies and research advances in synthesis of chemicals through bioconversion of methanol
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Xiaomei SUN, Xin WANG, Kequan CHEN*
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  • College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, Jiangsu, China
Published: 2026-09-04 doi: 10.13343/j.cnki.wsxb.20260366
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Achieving carbon peaking and carbon neutrality is a major strategic priority for China. Third-generation biomanufacturing, which uses one-carbon (C1) compounds such as methanol, carbon dioxide, and formic acid as feedstocks for bioconversion, has attracted increasing research interest. Among these C1 feedstocks, methanol is considered a promising substrate for biomanufacturing because of its ease of storage and transportation, high degree of reduction, and potential for large-scale production via CO2 hydrogenation. This review systematically compares natural and synthetic methanol assimilation pathways and elucidates their advantages. It further summarizes methanol metabolism in natural methylotrophic microorganisms and pathway design strategies for constructing synthetic methylotrophs, while also discussing the major challenges associated with methanol utilization. On this basis, this paper reviews recent progress in the methanol-based biosynthesis of various high-value chemicals and discusses the bottlenecks and corresponding engineering strategies for methanol bioconversion. This review provides a theoretical foundation for methanol-driven green biomanufacturing.

methanol  /  metabolic pathway  /  high-value chemical
Xiaomei SUN, Xin WANG, Kequan CHEN. Metabolic engineering strategies and research advances in synthesis of chemicals through bioconversion of methanol[J]. Acta Microbiologica Sinica, 2026 , 66 (9) : 4496 -4519 . DOI: 10.13343/j.cnki.wsxb.20260366
Funding
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  • the National Key Research and Development Program of China(2025YFA0922200)
Appendix
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Year 2026 volume 66 Issue 9
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134
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Article Info
doi: 10.13343/j.cnki.wsxb.20260366
  • Receive Date：2026-05-03
  • Online Date：2026-09-09
  • Published：2026-09-04
Article Data
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History
  • Received：2026-05-03
  • Accepted：2026-06-25
Funding
the National Key Research and Development Program of China(2025YFA0922200)
Affiliations
    College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, Jiangsu, China

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表12种不同金属材料的力学参数
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Family		 属数
Number of
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Number of
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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