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Design and construction of carbon dioxide fixation and transformation systems driven by synthetic microbial consortia
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Wei ZHAO1, 3, Tingting CHENG1, Qingyuan CHAI1, 2, Meiling BAN1, Jihuan DONG1, 2, Zhiyong HUANG1, 3, Yifan HAN1, 3, *
Acta Microbiologica Sinica | 2026, 66(9) : 4456 - 4470
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Acta Microbiologica Sinica | 2026, 66(9): 4456-4470
• Review •
Design and construction of carbon dioxide fixation and transformation systems driven by synthetic microbial consortia
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Wei ZHAO1, 3, Tingting CHENG1, Qingyuan CHAI1, 2, Meiling BAN1, Jihuan DONG1, 2, Zhiyong HUANG1, 3, Yifan HAN1, 3, *
Affiliations
  • 1.Tianjin Key Laboratory of Industrial Biological Systems and Process Engineering, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China
  • 2.College of Biotechnology, Tianjin University of Science and Technology, Tianjin, China
  • 3.National Technology Innovation Center for Synthetic Biology, Tianjin, China
About Author:

These authors contributed equally to this work.

Published: 2026-09-04 doi: 10.13343/j.cnki.wsxb.20260431
Outline
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With the proposal of carbon neutrality goals, microbial conversion of CO2 into high-value chemicals, fuels, and biomaterials has emerged as an important strategy for clean energy and green manufacturing. Although single-strain carbon fixation systems have ideal controllability, they still face limitations, including heavy metabolic burden, limited carbon fixation flux, insufficient energy and reducing power supply, low yield, and challenges in industrial-scale application. In contrast, synthetic microbial consortia enable rational metabolic division of labor among functionally distinct microorganisms, thereby alleviating metabolic burden, enhancing carbon fixation efficiency, and expanding product diversity. These advantages further improve product value and promote the industrial application of CO2 fixation. This review summarizes recent advances in the application of synthetic microbial consortia for CO2 conversion, including photosynthesis-driven systems, hydrogen-driven systems, and potentially safer chemoautotrophic systems classified according to carbon fixation modules. In addition, this paper discusses the design principles for constructing carbon cycling systems based on synthetic microbial consortia, together with current challenges and future perspectives, providing theoretical and practical guidance for the development of efficient and stable artificial carbon cycling systems.

synthetic microbial consortium  /  CO2 conversion  /  functional division of labor  /  metabolic cross-feeding  /  carbon fixation
Wei ZHAO, Tingting CHENG, Qingyuan CHAI, Meiling BAN, Jihuan DONG, Zhiyong HUANG, Yifan HAN. Design and construction of carbon dioxide fixation and transformation systems driven by synthetic microbial consortia[J]. Acta Microbiologica Sinica, 2026 , 66 (9) : 4456 -4470 . DOI: 10.13343/j.cnki.wsxb.20260431
Funding
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  • the Tianjin Science and Technology Program(24PTLYHZ00300)
  • the Tianjin Major Science and Technology Special Project and Engineering Project(25ZXWCSY00320)
  • the Tianjin Synthetic Biotechnology Innovation Capacity Improvement Action(TSBICIP-KJGG-039)
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Year 2026 volume 66 Issue 9
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97
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Article Info
doi: 10.13343/j.cnki.wsxb.20260431
  • Receive Date：2026-05-20
  • Online Date：2026-09-09
  • Published：2026-09-04
Article Data
Affiliations
History
  • Received：2026-05-20
  • Accepted：2026-06-28
Funding
the Tianjin Science and Technology Program(24PTLYHZ00300)
the Tianjin Major Science and Technology Special Project and Engineering Project(25ZXWCSY00320)
the Tianjin Synthetic Biotechnology Innovation Capacity Improvement Action(TSBICIP-KJGG-039)
Affiliations
    1.Tianjin Key Laboratory of Industrial Biological Systems and Process Engineering, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China
    2.College of Biotechnology, Tianjin University of Science and Technology, Tianjin, China
    3.National Technology Innovation Center for Synthetic Biology, Tianjin, China

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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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