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Research progress in the design and engineering of hydrogen-oxidizing bacteria
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Piao ZHANG1, 2, Zikang LU1, 3, Fei LI1, Chunling MA1, *, Zhiguang ZHU1, 2, *
Acta Microbiologica Sinica | 2026, 66(9) : 4420 - 4442
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Acta Microbiologica Sinica | 2026, 66(9): 4420-4442
• Review •
Research progress in the design and engineering of hydrogen-oxidizing bacteria
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Piao ZHANG1, 2, Zikang LU1, 3, Fei LI1, Chunling MA1, *, Zhiguang ZHU1, 2, *
Affiliations
  • 1.Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China
  • 2.University of Chinese Academy of Sciences, Beijing, China
  • 3.College of Life Sciences, Nankai University, Tianjin, China
About Author:

#These authors contributed equally to this work.

Published: 2026-09-04 doi: 10.13343/j.cnki.wsxb.20260357
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Against the backdrop of global climate change and resource scarcity, biological carbon fixation technologies driven by clean energy have emerged and attracted widespread attention. Hydrogen (H2), as a renewable and clean energy carrier with abundant sources and easy production, can serve as both the energy and the electron donor for microbial carbon fixation. This review summarizes the metabolic foundations of hydrogen-driven carbon-fixing chassis cells represented by hydrogen-oxidizing bacteria (HOB), and highlights recent advances in several representative strains. Furthermore, engineering strategies for HOB are discussed, including the development of enabling technologies, the reconstruction and reinforcement of metabolic pathways, and microbe-material coupling approaches. Additionally, this paper analyzes the current challenges facing HOB and proposes the future perspectives. Despite existing technical bottlenecks, with the advancement of metabolic engineering and systems biology, HOB are expected to play an important role in carbon recycling and sustainable biomanufacturing.

hydrogen-oxidizing bacteria  /  microbial carbon fixation  /  chemolithoautotrophs  /  chassis cell design
Piao ZHANG, Zikang LU, Fei LI, Chunling MA, Zhiguang ZHU. Research progress in the design and engineering of hydrogen-oxidizing bacteria[J]. Acta Microbiologica Sinica, 2026 , 66 (9) : 4420 -4442 . DOI: 10.13343/j.cnki.wsxb.20260357
Funding
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  • the Strategic Priority Research Program of Chinese Academy of Sciences(XDC0120300)
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Year 2026 volume 66 Issue 9
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Article Info
doi: 10.13343/j.cnki.wsxb.20260357
  • Receive Date：2026-04-30
  • Online Date：2026-09-09
  • Published：2026-09-04
Article Data
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History
  • Received：2026-04-30
  • Accepted：2026-07-07
Funding
the Strategic Priority Research Program of Chinese Academy of Sciences(XDC0120300)
Affiliations
    1.Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China
    2.University of Chinese Academy of Sciences, Beijing, China
    3.College of Life Sciences, Nankai University, Tianjin, China

Corresponding:

*E-mail: MA Chunling,
ZHU Zhiguang,
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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