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Design and construction of microbial carbon fixation pathways empowered by synthetic biology
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Jiayin ZHANG1, 2, Yanping ZHANG1, Yin LI1, Huawei ZHU1, *
Acta Microbiologica Sinica | 2026, 66(9) : 4341 - 4361
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Acta Microbiologica Sinica | 2026, 66(9): 4341-4361
• Review •
Design and construction of microbial carbon fixation pathways empowered by synthetic biology
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Jiayin ZHANG1, 2, Yanping ZHANG1, Yin LI1, Huawei ZHU1, *
Affiliations
  • 1.State Key Laboratory of Microbial Diversity and Innovative Utilization, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China
  • 2.University of Chinese Academy of Sciences, Beijing, China
Published: 2026-09-04 doi: 10.13343/j.cnki.wsxb.20260309
Outline
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Microbial carbon fixation represents a crucial negative emission technology for achieving the carbon peaking and carbon neutrality goals and serves as a primary source of raw materials for the next generation of biomanufacturing. However, naturally occurring carbon fixation pathways generally suffer from limitations such as slow carboxylation rates, harsh reaction conditions, and difficulties in heterologous reconstruction. In recent years, scientists have designed and constructed several synthetic carbon fixation pathways, establishing a foundation for developing efficient biological carbon fixation systems. This article systematically reviews the naturally discovered carbon fixation pathways and summarizes the key advances in the modification of natural pathways and the design of synthetic carbon fixation pathways empowered by synthetic biology. Furthermore, it summarizes recent progress in energy supply strategies for microbial carbon fixation. Finally, we discuss the bottlenecks and optimization strategies, providing scientific insights and perspectives for the development of efficient carbon fixation systems for practical applications.

microbial carbon fixation  /  synthetic biology  /  carbon fixation pathway  /  energy supply
Jiayin ZHANG, Yanping ZHANG, Yin LI, Huawei ZHU. Design and construction of microbial carbon fixation pathways empowered by synthetic biology[J]. Acta Microbiologica Sinica, 2026 , 66 (9) : 4341 -4361 . DOI: 10.13343/j.cnki.wsxb.20260309
Funding
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  • the Beijing-Tianjin-Hebei Natural Science Foundation Cooperation Project(25JJJJC0036)
  • the National Natural Science Foundation of China(32571657)
Appendix
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Year 2026 volume 66 Issue 9
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147
69
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Article Info
doi: 10.13343/j.cnki.wsxb.20260309
  • Receive Date：2026-04-16
  • Online Date：2026-09-09
  • Published：2026-09-04
Article Data
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History
  • Received：2026-04-16
  • Accepted：2026-06-08
Funding
the Beijing-Tianjin-Hebei Natural Science Foundation Cooperation Project(25JJJJC0036)
the National Natural Science Foundation of China(32571657)
Affiliations
    1.State Key Laboratory of Microbial Diversity and Innovative Utilization, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China
    2.University of Chinese Academy of Sciences, Beijing, China

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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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