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Research progress in the construction and optimization of an efficient heterologous protein expression system with Trichoderma reesei as the chassis
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Jingzhuo HOU1, 2, Haiyan LI1, Ying LIU2, Xiaowei PENG2
Acta Microbiologica Sinica | 2026, 66(8) : 3793 - 3808
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Acta Microbiologica Sinica | 2026, 66(8): 3793-3808
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Research progress in the construction and optimization of an efficient heterologous protein expression system with Trichoderma reesei as the chassis
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Jingzhuo HOU1, 2, Haiyan LI1, Ying LIU2, Xiaowei PENG2
Affiliations
  • 1.College of Environmental and Safety Engineering, Shenyang University of Chemical Technology, Shenyang, Liaoning, China
  • 2.State Key Laboratory of Biopharmaceutical Preparation and Delivery, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, China
Published: 2026-08-04 doi: 10.13343/j.cnki.wsxb.20260151
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Trichoderma reesei is recognized as the microorganism with the most potent protein secretion capability known to date. It is extensively utilized for cellulase production and has garnered significant attention in heterologous protein synthesis. Although notable progress has been achieved in the screening of expression elements, chassis engineering, and fermentation process optimization, critical challenges persist, and the large-scale industrial application of heterologous protein expression has not yet been fully realized. This paper reviews the strategies and recent research advances regarding the high-efficiency expression of heterologous proteins in T. reesei. Furthermore, this paper discusses the limiting factors for its industrial-scale application and proposes novel recommendations and strategies to enhance heterologous protein yields.

Trichoderma reesei  /  heterologous protein production  /  high-efficiency expression strategies  /  protease
Jingzhuo HOU, Haiyan LI, Ying LIU, Xiaowei PENG. Research progress in the construction and optimization of an efficient heterologous protein expression system with Trichoderma reesei as the chassis[J]. Acta Microbiologica Sinica, 2026 , 66 (8) : 3793 -3808 . DOI: 10.13343/j.cnki.wsxb.20260151
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  • National Natural Science Foundation of China(22478403)
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Year 2026 volume 66 Issue 8
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Article Info
doi: 10.13343/j.cnki.wsxb.20260151
  • Receive Date：2026-02-24
  • Online Date：2026-08-21
  • Published：2026-08-04
Article Data
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History
  • Received：2026-02-24
  • Accepted：2026-04-02
Funding
National Natural Science Foundation of China(22478403)
Affiliations
    1.College of Environmental and Safety Engineering, Shenyang University of Chemical Technology, Shenyang, Liaoning, China
    2.State Key Laboratory of Biopharmaceutical Preparation and Delivery, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, China

Corresponding:

E-mail: LI Haiyan, ;
PENG Xiaowei,
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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