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Akkermansia muciniphila: functional exploration and application progress
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Yunxuan JIANG1, 2, Ying LIU2, Yan WANG2, Zhong YU1, Yi WAN2
Acta Microbiologica Sinica | 2026, 66(8) : 3771 - 3792
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Acta Microbiologica Sinica | 2026, 66(8): 3771-3792
• Review •
Akkermansia muciniphila: functional exploration and application progress
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Yunxuan JIANG1, 2, Ying LIU2, Yan WANG2, Zhong YU1, Yi WAN2
Affiliations
  • 1.School of Eco-environmental & Chemical Engineering, Xi’an University of Technology, Xi’an, Shaanxi, China
  • 2.Shaanxi Institute of Microbiology, Xi’an, Shaanxi, China
About Author:

These authors contributed equally to this work.

Published: 2026-08-04 doi: 10.13343/j.cnki.wsxb.20260143
Outline
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As a key group of the gut microbiota that helps maintain intestinal homeostasis, probiotics have attracted significant attention in life science and medical research. Akkermansia muciniphila (AKK), a strictly anaerobic Gram-negative bacterium, has swiftly become a central topic in gut microbiota research owing to its unique metabolic properties and considerable probiotic potential. This review systematically summarizes the discovery, physiological characteristics, and isolation methodologies and screening of AKK, while placing a particular emphasis on its role in preventing and managing a spectrum of human and animal diseases (including tumors, neurodegenerative disorders, metabolic syndromes, and inflammatory bowel diseases), thereby offering novel perspectives and potential targets for disease intervention. Furthermore, this review elucidates the core mechanisms underlying the probiotic functions of AKK. Specifically, AKK exerts beneficial effects on host health and therapeutic effects on diseases primarily through three key pathways: modulating intestinal microecological balance and barrier integrity, regulating systemic metabolic processes and immune responses, and mediating intricate crosstalk between the intestine and multiple extra-intestinal systems. To assess the translational efficiency of AKK, we summarize the current application status of its functional-related proteins and preparations in health, analyze clinical application scenarios and potential, and discuss existing bottlenecks and challenges in industrial application. This review provides a comprehensive theoretical reference and directional guidance for future basic research, application development, and industrialization of AKK.

Akkermansia muciniphila  /  disease prevention and control  /  probiotic mechanism  /  active protein  /  clinical transformation
Yunxuan JIANG, Ying LIU, Yan WANG, Zhong YU, Yi WAN. Akkermansia muciniphila: functional exploration and application progress[J]. Acta Microbiologica Sinica, 2026 , 66 (8) : 3771 -3792 . DOI: 10.13343/j.cnki.wsxb.20260143
Funding
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  • National Natural Science Foundation of China(32400109)
  • Agricultural Technology Research and Development Project of Xi’an Municipal Bureau of Science and Technology(24NYGG027)
  • Basic Research Project of Shaanxi Academy of Sciences(2024k-22)
  • Sanqin Talents Special Support Program of Shaanxi Province
Appendix
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Year 2026 volume 66 Issue 8
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462
198
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Article Info
doi: 10.13343/j.cnki.wsxb.20260143
  • Receive Date：2026-02-19
  • Online Date：2026-08-21
  • Published：2026-08-04
Article Data
Affiliations
History
  • Received：2026-02-19
  • Accepted：2026-04-24
Funding
National Natural Science Foundation of China(32400109)
Agricultural Technology Research and Development Project of Xi’an Municipal Bureau of Science and Technology(24NYGG027)
Basic Research Project of Shaanxi Academy of Sciences(2024k-22)
Sanqin Talents Special Support Program of Shaanxi Province
Affiliations
    1.School of Eco-environmental & Chemical Engineering, Xi’an University of Technology, Xi’an, Shaanxi, China
    2.Shaanxi Institute of Microbiology, Xi’an, Shaanxi, China

Corresponding:

E-mail: YU Zhong, ;
WAN Yi,
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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