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Research progress in gut microbiota dysregulation in ulcerative colitis and its regulation by traditional Chinese medicine
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Yating CAO1, 2, Xin HUANG1, 2, Peipeng CHEN3, Xue HAN1, 2, Hui WANG3, Chenwen WANG3, Zhiheng GONG3, Haowei YU3, Wanting PENG3, Yuning SA1, 2, Yongming LI4, Wei ZHOU3, Ailing YIN1, 2
Acta Microbiologica Sinica | 2026, 66(8) : 3695 - 3717
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Acta Microbiologica Sinica | 2026, 66(8): 3695-3717
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Research progress in gut microbiota dysregulation in ulcerative colitis and its regulation by traditional Chinese medicine
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Yating CAO1, 2, Xin HUANG1, 2, Peipeng CHEN3, Xue HAN1, 2, Hui WANG3, Chenwen WANG3, Zhiheng GONG3, Haowei YU3, Wanting PENG3, Yuning SA1, 2, Yongming LI4, Wei ZHOU3, Ailing YIN1, 2
Affiliations
  • 1.Medical Experimental Centre, Central Laboratory, Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China
  • 2.Department of Biobank, Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China
  • 3.State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu, China
  • 4.School of Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China
Published: 2026-08-04 doi: 10.13343/j.cnki.wsxb.20260062
Outline
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Ulcerative colitis (UC) is a chronic non-specific intestinal inflammatory disease with complex pathogenesis. Recent studies have identified a pivotal role of the gut microbiota in the etiology of the disease. Beneficial bacteria, such as Lactobacillus and Bifidobacterium, have been shown to regulate the balance of the gut microbiota, repair the mucosal barrier, and alleviate inflammation. In contrast, excessive proliferation or secretion of toxins by harmful bacteria, such as Escherichia, can damage the integrity of the mucosa, induce inflammation, and accelerate the progression of UC. The active ingredients of traditional Chinese medicine, such as Scutellariae radix polysaccharides, pulchinenosides, and ginsenoside Rg1, may offer a promising avenue for the treatment of UC by modulating the structure of the gut microbiota and enhancing the barrier function and mucosal integrity. The present article reviews the latest research progress in the regulation mechanism of the gut microbiota in UC and the traditional Chinese medicine intervention, with a view to providing new strategies and theoretical support for clinical treatment.

ulcerative colitis  /  gut microbiota  /  Lactobacillus acidophilus  /  Bifidobacterium longum  /  Clostridioides difficile  /  regulation by traditional Chinese medicine
Yating CAO, Xin HUANG, Peipeng CHEN, Xue HAN, Hui WANG, Chenwen WANG, Zhiheng GONG, Haowei YU, Wanting PENG, Yuning SA, Yongming LI, Wei ZHOU, Ailing YIN. Research progress in gut microbiota dysregulation in ulcerative colitis and its regulation by traditional Chinese medicine[J]. Acta Microbiologica Sinica, 2026 , 66 (8) : 3695 -3717 . DOI: 10.13343/j.cnki.wsxb.20260062
Funding
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  • Jiangsu Provincial Research Project on Traditional Chinese Medicine and Integrated Traditional Chinese and Western Medicine(ZXFZ2026034)
  • Natural Science Foundation of Nanjing University of Chinese Medicine(XZR2024096)
Appendix
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Year 2026 volume 66 Issue 8
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Article Info
doi: 10.13343/j.cnki.wsxb.20260062
  • Receive Date：2026-01-22
  • Online Date：2026-08-21
  • Published：2026-08-04
Article Data
Affiliations
History
  • Received：2026-01-22
  • Accepted：2026-04-08
Funding
Jiangsu Provincial Research Project on Traditional Chinese Medicine and Integrated Traditional Chinese and Western Medicine(ZXFZ2026034)
Natural Science Foundation of Nanjing University of Chinese Medicine(XZR2024096)
Affiliations
    1.Medical Experimental Centre, Central Laboratory, Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China
    2.Department of Biobank, Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China
    3.State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu, China
    4.School of Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China

Corresponding:

E-mail: YIN Ailing, ;
ZHOU Wei,
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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