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Research progress in microbial synthesis of eumelanin
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Xiaobing YANG1, Jing ZHANG1, Haijun GAO2
Acta Microbiologica Sinica | 2026, 66(8) : 3681 - 3694
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Acta Microbiologica Sinica | 2026, 66(8): 3681-3694
• Review •
Research progress in microbial synthesis of eumelanin
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Xiaobing YANG1, Jing ZHANG1, Haijun GAO2
Affiliations
  • 1.School of Chemical Engineering, Zhengzhou University, Zhengzhou, Henan, China
  • 2.School of Life Science, Beijing Institute of Technology, Beijing, China
Published: 2026-08-04 doi: 10.13343/j.cnki.wsxb.20260054
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Eumelanin, a natural biological pigment formed by the polymerization of 5,6-dihydroxyindole and its carboxylic acid derivatives, is ubiquitous in animals and microorganisms. Its highly conjugated molecular structure confers multiple functional properties, including broad-spectrum light absorption, antioxidant activity, free radical scavenging, and metal ion chelation, making it a promising material for applications in biomedicine, functional coatings, and environmental remediation. The conventional production of eumelanin relies largely on extraction from animal tissue or chemical synthesis, which are constrained by limited raw materials and uncontrollable product structures. Recently, microbial cell factory-based biosynthesis of eumelanin has attracted increasing attention due to its environmental sustainability and structural controllability. This review comprehensively summarizes the biosynthetic pathways, strategies for metabolic engineering and genetic engineering, analysis and characterization methods for eumelanin, and discusses future perspectives for the application and development of microbial eumelanin production.

eumelanin  /  microbial synthesis  /  microbial cell factory  /  analysis and characterization
Xiaobing YANG, Jing ZHANG, Haijun GAO. Research progress in microbial synthesis of eumelanin[J]. Acta Microbiologica Sinica, 2026 , 66 (8) : 3681 -3694 . DOI: 10.13343/j.cnki.wsxb.20260054
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Year 2026 volume 66 Issue 8
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Article Info
doi: 10.13343/j.cnki.wsxb.20260054
  • Receive Date：2026-01-20
  • Online Date：2026-08-21
  • Published：2026-08-04
Article Data
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History
  • Received：2026-01-20
  • Accepted：2026-03-29
Affiliations
    1.School of Chemical Engineering, Zhengzhou University, Zhengzhou, Henan, China
    2.School of Life Science, Beijing Institute of Technology, Beijing, China

Corresponding:

E-mail: GAO Haijun, ;
ZHANG Jing,
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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