Home Journals Articles Updates About
CN
image
收藏切换
Inhibitory activity and mechanism of action of isopsoralen against Pseudomonas amygdali pv. lachrymans
收藏切换
PDF
Jingxin GAO1, Lingyun LIU2, Xiaoqian LI2, Lijie GUAN2
Acta Microbiologica Sinica | 2026, 66(8) : 3839 - 3850
Less
收藏切换
Acta Microbiologica Sinica | 2026, 66(8): 3839-3850
• Research Article •
Inhibitory activity and mechanism of action of isopsoralen against Pseudomonas amygdali pv. lachrymans
Full
Jingxin GAO1, Lingyun LIU2, Xiaoqian LI2, Lijie GUAN2
Affiliations
  • 1.College of Chemical Engineering, Shenyang University of Chemical Technology, Shenyang, Liaoning, China
  • 2.College of Environmental and Safety Engineering, Shenyang University of Chemical Technology, Shenyang, Liaoning, China
Published: 2026-08-04 doi: 10.13343/j.cnki.wsxb.20260082
Outline
收藏切换

[Objective] To elucidate the primary bioactive component in Psoralea corylifolia seed extract that is responsible for inhibiting Pseudomonas amygdali pv. lachrymans (Pal) and to characterize its antibacterial mechanism. [Methods] The effect of isopsoralen on the growth curve of Pal and its minimum inhibitory concentration (MIC) were determined by the liquid culture assay. The antibacterial mechanism was investigated by transmission electron microscopy (TEM) combined with physiological and biochemical analyses. [Results] The MIC of isopsoralen against Pal was 400 mg/L. Isopsoralen disrupted the integrity of the bacterial cell wall and cell membrane, leading to leakage of intracellular contents. It interfered with cellular energy metabolism by inhibiting the activity of respiratory chain dehydrogenases. In addition, it impaired bacterial responses to environmental changes and colonization in the host by suppressing swarming motility, swimming motility, and biofilm formation. [Conclusion] Isopsoralen exerts its inhibitory activity against Pal through the synergistic actions of structural damage, energy disruption, and virulence suppression, ultimately abolishing the pathogen’s ability to infect the host. These findings provide a theoretical basis for the application of P. corylifolia seed extract as a botanical bactericide in the green management of cucumber bacterial angular leaf spot.

isopsoralen  /  Pseudomonas amygdali pv. lachrymans  /  physiological and biochemical mechanism
Jingxin GAO, Lingyun LIU, Xiaoqian LI, Lijie GUAN. Inhibitory activity and mechanism of action of isopsoralen against Pseudomonas amygdali pv. lachrymans[J]. Acta Microbiologica Sinica, 2026 , 66 (8) : 3839 -3850 . DOI: 10.13343/j.cnki.wsxb.20260082
Funding
Less
  • National Key Research and Development Program of China(SQ2020YFF0411744)
Appendix
Less
Year 2026 volume 66 Issue 8
PDF
318
138
Cite this Article
BibTeX
Article Info
doi: 10.13343/j.cnki.wsxb.20260082
  • Receive Date：2026-01-27
  • Online Date：2026-08-21
  • Published：2026-08-04
Article Data
Affiliations
History
  • Received：2026-01-27
  • Accepted：2026-04-13
Funding
National Key Research and Development Program of China(SQ2020YFF0411744)
Affiliations
    1.College of Chemical Engineering, Shenyang University of Chemical Technology, Shenyang, Liaoning, China
    2.College of Environmental and Safety Engineering, Shenyang University of Chemical Technology, Shenyang, Liaoning, China

Corresponding:

References
Share
https://castjournals.cast.org.cn/joweb/wswxb/EN/10.13343/j.cnki.wsxb.20260082
Share to
QR

Scan QR to access full text

Cite this article
BibTeX
Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏
  • BibTeX
  • EndNote
  • RefWorks
  • TxT
Links
Articles
Latest Articles
Most Read
Collections
Updates
Events
News
Multimedia
About
About Us
Contact
No. 86 Xueyuan South Road, Haidian District, Beijing
100081
010-62199257
qkjq@cast.org.cn

Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House