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Protective effects of Camphora kanahirae leaves on gut microbiota and short-chain fatty acid metabolism in the mouse model of alcoholic liver disease
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Peiyao TAN1, Xuezheng LIANG2, Jianwei LÜ3, Xiaomin YANG4, Bei ZHANG3
Acta Microbiologica Sinica | 2026, 66(8) : 3913 - 3925
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Acta Microbiologica Sinica | 2026, 66(8): 3913-3925
• Research Article •
Protective effects of Camphora kanahirae leaves on gut microbiota and short-chain fatty acid metabolism in the mouse model of alcoholic liver disease
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Peiyao TAN1, Xuezheng LIANG2, Jianwei LÜ3, Xiaomin YANG4, Bei ZHANG3
Affiliations
  • 1.Guangxi University of Chinese Medicine, Nanning, Guangxi, China
  • 2.Liuzhou Traditional Chinese Medicine Hospital, Liuzhou, Guangxi, China
  • 3.The First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning, Guangxi, China
  • 4.Liuzhou Maternity and Child Healthcare Hospital, Liuzhou, Guangxi, China
Published: 2026-08-04 doi: 10.13343/j.cnki.wsxb.20260055
Outline
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[Objective] To investigate the mechanism by which Camphora kanahirae leaves alleviate alcoholic liver disease through the regulation of the gut microbiota-short-chain fatty acid-intestinal barrier pathway. [Methods] Sixty mice were randomly allocated into six groups [normal, model, silymarin (100 mg/kg), and low-, medium-, and high-dose (100, 200, and 400 mg/kg, respectively) C. kanahirae leaves], with 10 mice in each group. After 14 consecutive days of administration, a mouse model of alcoholic liver disease was established. The liver index, alanine aminotransferase (ALT) and aspartate transferase (AST) levels, colon histopathological changes, short-chain fatty acid content, and alterations in gut microbiota structure were measured. [Results] Compared with the model group, medium- and high-dose C. kanahirae leaves reduced ALT and AST levels (P<0.05). Pathological evaluation showed that C. kanahirae leaves at all doses alleviated alcohol-induced colon mucosal damage and inflammatory cell infiltration to varying degrees. Alcohol damage resulted in decreases in levels of short-chain fatty acids, such as acetic acid, propionic acid, butyric acid, and valeric acid (P<0.05). C. kanahirae leaves promoted the proliferation of beneficial bacteria, increased short-chain fatty acid levels, and enhanced intestinal barrier function. Furthermore, 16S rRNA gene analysis of the gut microbiota indicated that alcohol intake led to dysbiosis, and C. kanahirae leaves effectively reversed this microbial imbalance, restoring the composition and diversity of the gut microbiota. [Conclusion] C. kanahirae leaves exert hepatoprotective effects by regulating the gut microbiota balance, promoting short-chain fatty acid production, and maintaining intestinal barrier integrity.

Camphora kanahirae leaf  /  alcoholic liver disease  /  short-chain fatty acid  /  gut microbiota
Peiyao TAN, Xuezheng LIANG, Jianwei LÜ, Xiaomin YANG, Bei ZHANG. Protective effects of Camphora kanahirae leaves on gut microbiota and short-chain fatty acid metabolism in the mouse model of alcoholic liver disease[J]. Acta Microbiologica Sinica, 2026 , 66 (8) : 3913 -3925 . DOI: 10.13343/j.cnki.wsxb.20260055
Funding
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  • National Training Program for Inheriting Talents of Characteristic Technologies in Traditional Chinese Medicine(T20234832005)
  • Innovation Project of Guangxi Graduate Education of GXUCM(YCSY2025096)
Appendix
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Year 2026 volume 66 Issue 8
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276
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Article Info
doi: 10.13343/j.cnki.wsxb.20260055
  • Receive Date：2026-01-20
  • Online Date：2026-08-21
  • Published：2026-08-04
Article Data
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History
  • Received：2026-01-20
  • Accepted：2026-02-27
Funding
National Training Program for Inheriting Talents of Characteristic Technologies in Traditional Chinese Medicine(T20234832005)
Innovation Project of Guangxi Graduate Education of GXUCM(YCSY2025096)
Affiliations
    1.Guangxi University of Chinese Medicine, Nanning, Guangxi, China
    2.Liuzhou Traditional Chinese Medicine Hospital, Liuzhou, Guangxi, China
    3.The First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning, Guangxi, China
    4.Liuzhou Maternity and Child Healthcare Hospital, Liuzhou, Guangxi, China

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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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