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Research progress in the role of key metabolites of gut microbiota in the progression of Alzheimer’s disease
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Jianxing ZHENG1, 2, Mengqing ZHAO3, Yunchen LUO2, Tiegang XIAO2, Yueshuang ZHAO4, Shuqing ZHAO3, Jun XU2, Bing WANG2
Acta Microbiologica Sinica | 2026, 66(7) : 3139 - 3149
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Acta Microbiologica Sinica | 2026, 66(7): 3139-3149
• Review •
Research progress in the role of key metabolites of gut microbiota in the progression of Alzheimer’s disease
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Jianxing ZHENG1, 2, Mengqing ZHAO3, Yunchen LUO2, Tiegang XIAO2, Yueshuang ZHAO4, Shuqing ZHAO3, Jun XU2, Bing WANG2
Affiliations
  • 1.Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, China
  • 2.Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
  • 3.Shanghai University of Traditional Chinese Medicine, Shanghai, China
  • 4.Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, China
Published: 2026-07-04 doi: 10.13343/j.cnki.wsxb.20250916
Outline
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Alzheimer’s disease (AD) is a complex neurodegenerative disorder characterized by progressive cognitive impairment. In recent years, the “gut-brain axis” has been recognized to play an important role in the pathogenesis of AD, with the gut microbiota-derived metabolites serving as key mediators of gut-brain communication. This review systematically summarizes the alterations and underlying molecular mechanisms of five classes of key metabolites—short-chain fatty acids, bile acids, indole derivatives, trimethylamine N-oxide, and lipopolysaccharides—during the progression of AD. This review not only provides new perspectives for understanding the pathological processes of AD but also lays a theoretical foundation for the development of diagnostic and therapeutic strategies based on microbiota modulation.

Alzheimer’s disease  /  short-chain fatty acids  /  bile acids  /  indole derivatives  /  trimethylamine N-oxide  /  lipopolysaccharides
Jianxing ZHENG, Mengqing ZHAO, Yunchen LUO, Tiegang XIAO, Yueshuang ZHAO, Shuqing ZHAO, Jun XU, Bing WANG. Research progress in the role of key metabolites of gut microbiota in the progression of Alzheimer’s disease[J]. Acta Microbiologica Sinica, 2026 , 66 (7) : 3139 -3149 . DOI: 10.13343/j.cnki.wsxb.20250916
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  • the National Flagship Department of Integrated Chinese and Western Medicine Collaboration of the National Health Commission((2024)221)
Appendix
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Year 2026 volume 66 Issue 7
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Article Info
doi: 10.13343/j.cnki.wsxb.20250916
  • Receive Date：2025-12-08
  • Online Date：2026-07-06
  • Published：2026-07-04
Article Data
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History
  • Received：2025-12-08
  • Accepted：2026-03-17
Funding
the National Flagship Department of Integrated Chinese and Western Medicine Collaboration of the National Health Commission((2024)221)
Affiliations
    1.Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, China
    2.Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
    3.Shanghai University of Traditional Chinese Medicine, Shanghai, China
    4.Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, China

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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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