Home Journals Articles Updates About
CN
image
收藏切换
Role of butyrate-producing bacteria in the progression of neurodegenerative diseases
收藏切换
PDF
Ziying ZHANG1, 2, Yanping CHENG1, 2, Xinyao SONG1, 2, Yueran MA3, Yuemeng ZHANG4, Wei WANG1, 2, Yanan LEI1, 2, Jiaxi YAO1, 2, Shuxiang LI1, 2, Yuhong LYU1, 2
Acta Microbiologica Sinica | 2026, 66(7) : 3150 - 3161
Less
收藏切换
Acta Microbiologica Sinica | 2026, 66(7): 3150-3161
• Review •
Role of butyrate-producing bacteria in the progression of neurodegenerative diseases
Full
Ziying ZHANG1, 2, Yanping CHENG1, 2, Xinyao SONG1, 2, Yueran MA3, Yuemeng ZHANG4, Wei WANG1, 2, Yanan LEI1, 2, Jiaxi YAO1, 2, Shuxiang LI1, 2, Yuhong LYU1, 2
Affiliations
  • 1.Yan’an Medical College, Yan’an University, Yan’an, Shaanxi, China
  • 2.Yan’an Key Laboratory of Microbial Drug Innovation and Transformation, Yan’an, Shaanxi, China
  • 3.Department of Pathology, Yan’an Hospital of Traditional Chinese Medicine, Yan’an, Shaanxi, China
  • 4.Department of Pathology, The First People’s Hospital of Xianyang, Xianyang, Shaanxi, China
Published: 2026-07-04 doi: 10.13343/j.cnki.wsxb.20260021
Outline
收藏切换

Neurodegenerative diseases, a group of highly prevalent central nervous system disorders, are closely linked to gut microbiota dysbiosis and impaired gut-brain axis function. The emerging gut-brain axis theory offers a novel perspective to explain how microbes exert remote, cross-organ regulation over the central nervous system. Recent studies have indicated that butyrate-producing bacteria, a core functional component of the gut microbiota, exhibit dynamic changes temporally and spatially correlated with the onset and progression of these diseases. These bacteria are thought to modulate the central nervous system microenvironment and disease pathology via the gut-brain axis. This article systematically reviews the bidirectional signaling mechanisms between the gut microbiota and the brain, analyzing the complex, multidimensional relationship between butyrate-producing bacteria and neurodegenerative diseases. This analysis encompasses population heterogeneity in patients with diverse clinical features and the dynamic evolution of these bacterial communities across different disease stages. We summarize the key mechanisms by which butyrate-producing bacteria regulate disease progression, including barrier protection, immunomodulation, metabolic regulation, and epigenetic modification. Furthermore, we explore their clinical potential as predictive biomarkers and therapeutic targets. We propose that future research should prioritize the development of targeted intervention strategies for gut-derived butyrate-producing bacteria. This review aims to provide a theoretical foundation and novel insights to advance both the fundamental investigation and clinical translation of these bacteria in the context of neurodegenerative diseases.

gut-brain axis  /  neurodegenerative disease  /  butyrate-producing bacteria  /  mechanisms of action  /  biomarkers
Ziying ZHANG, Yanping CHENG, Xinyao SONG, Yueran MA, Yuemeng ZHANG, Wei WANG, Yanan LEI, Jiaxi YAO, Shuxiang LI, Yuhong LYU. Role of butyrate-producing bacteria in the progression of neurodegenerative diseases[J]. Acta Microbiologica Sinica, 2026 , 66 (7) : 3150 -3161 . DOI: 10.13343/j.cnki.wsxb.20260021
Funding
Less
  • The Innovation and Entrepreneurship Program of Shaanxi Province(S202410719149)
  • The Yan’an Science and Technology Program(2025-SFGG-047)
  • The Xianyang Key Research and Development Program(L2025-ZDYF-ZYY-019)
  • The Yan’an University College Students’ Innovation and Entrepreneurship Program(D2023170)
Appendix
Less
Year 2026 volume 66 Issue 7
PDF
232
123
Cite this Article
BibTeX
Article Info
doi: 10.13343/j.cnki.wsxb.20260021
  • Receive Date：2026-01-08
  • Online Date：2026-07-06
  • Published：2026-07-04
Article Data
Affiliations
History
  • Received：2026-01-08
  • Accepted：2026-03-08
Funding
The Innovation and Entrepreneurship Program of Shaanxi Province(S202410719149)
The Yan’an Science and Technology Program(2025-SFGG-047)
The Xianyang Key Research and Development Program(L2025-ZDYF-ZYY-019)
The Yan’an University College Students’ Innovation and Entrepreneurship Program(D2023170)
Affiliations
    1.Yan’an Medical College, Yan’an University, Yan’an, Shaanxi, China
    2.Yan’an Key Laboratory of Microbial Drug Innovation and Transformation, Yan’an, Shaanxi, China
    3.Department of Pathology, Yan’an Hospital of Traditional Chinese Medicine, Yan’an, Shaanxi, China
    4.Department of Pathology, The First People’s Hospital of Xianyang, Xianyang, Shaanxi, China

Corresponding:

E-mail: LI Shuxiang,
LYU Yuhong,
References
Share
https://castjournals.cast.org.cn/joweb/wswxb/EN/10.13343/j.cnki.wsxb.20260021
Share to
QR

Scan QR to access full text

Cite this article
BibTeX
Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏
  • BibTeX
  • EndNote
  • RefWorks
  • TxT
Links
Articles
Latest Articles
Most Read
Collections
Updates
Events
News
Multimedia
About
About Us
Contact
No. 86 Xueyuan South Road, Haidian District, Beijing
100081
010-62199257
qkjq@cast.org.cn

Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House