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Isolation, identification, and bioactivity screening of dioscysmycine A and polyketones from the deep-sea-derived fungus Talaromycesmuroii SCSIO 40439
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Miaomiao YIN1, 2, Xuemin DING2, 3, Tianyu ZHOU2, 3, Xiaoyu LIU2, 3, Changsheng ZHANG2, 3, Mingguo JIANG1, Wenjun ZHANG2, 3
Acta Microbiologica Sinica | 2026, 66(6) : 2988 - 3001
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Acta Microbiologica Sinica | 2026, 66(6): 2988-3001
• Research Article •
Isolation, identification, and bioactivity screening of dioscysmycine A and polyketones from the deep-sea-derived fungus Talaromycesmuroii SCSIO 40439
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Miaomiao YIN1, 2, Xuemin DING2, 3, Tianyu ZHOU2, 3, Xiaoyu LIU2, 3, Changsheng ZHANG2, 3, Mingguo JIANG1, Wenjun ZHANG2, 3
Affiliations
  • 1.Guangxi Key Laboratory of Polysaccharide Materials and Modification, Guangxi-Indonesia Joint Laboratory for Intelligent Mining of Microbial Resources, School of Marine Sciences and Biotechnology, Guangxi Minzu University, Nanning, Guangxi, China
  • 2.State Key Laboratory of Tropical Oceanography, Laboratory of Tropical Marine Bio-Resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, Guangdong, China
  • 3.University of Chinese Academy of Sciences, Beijing, China
Published: 2026-06-04 doi: 10.13343/j.cnki.wsxb.20260110
Outline
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Objective To isolate and identify secondary metabolites from the deep-sea-derived fungus Talaromyces muroii SCSIO 40439 and evaluate their biological activities. Methods The strain SCSIO 40439 was fermented on a rice medium. The resulting extract was subjected to silica gel column, Sephadex LH-20 column, and semipreparative high performance liquid chromatography (HPLC) to obtain compounds. Structure elucidation was performed via high-resolution electrospray ionization mass spectrum (HRESIMS), nuclear magnetic resonance (NMR), and X-ray crystal diffraction and comparison with literature data. Antimicrobial activity was assessed through the filter paper disk diffusion method, while tyrosinase inhibitory activity was measured based on the rate of dopamine oxidation. Results Four compounds were isolated from the fermentation extract of T. muroii SCSIO 40439, including a new orsellinic acid-cysteine dimer dioscysmycine A (1) and three known polyketides: alternariol (2), altenusin (3), and 3′-hydroxyalternariol 5-O-methyl ether (4). Compound 1 exhibited tyrosinase inhibitory activity with an inhibition rate of 58% (the positive control, kojic acid, showed an inhibition rate of 90%). Compound 2 inhibited the growth of Staphylococcus aureus ATCC 29213 and methicillin-resistant S. aureus ATCC 43300. Conclusion This study expands the known structural diversity of secondary metabolites of Talaromyces and identified a candidate inhibitor for tyrosinase. Furthermore, the findings provide a new biosynthetic gene cluster of alternariol.

deep-sea-derived Talaromyces  /  orsellinic acid-cysteine dimer  /  tyrosinase inhibitory activity
Miaomiao YIN, Xuemin DING, Tianyu ZHOU, Xiaoyu LIU, Changsheng ZHANG, Mingguo JIANG, Wenjun ZHANG. Isolation, identification, and bioactivity screening of dioscysmycine A and polyketones from the deep-sea-derived fungus Talaromycesmuroii SCSIO 40439[J]. Acta Microbiologica Sinica, 2026 , 66 (6) : 2988 -3001 . DOI: 10.13343/j.cnki.wsxb.20260110
Funding
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  • the National Natural Science Foundation of China(42176127)
  • the National Natural Science Foundation of China(32460009)
  • the Natural Science Foundation of Guangdong Province(2024A1515011056)
Appendix
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Year 2026 volume 66 Issue 6
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22
8
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Article Info
doi: 10.13343/j.cnki.wsxb.20260110
  • Receive Date：2026-02-05
  • Online Date：2026-06-17
  • Published：2026-06-04
Article Data
Affiliations
History
  • Received：2026-02-05
  • Accepted：2026-03-16
Funding
the National Natural Science Foundation of China(42176127)
the National Natural Science Foundation of China(32460009)
the Natural Science Foundation of Guangdong Province(2024A1515011056)
Affiliations
    1.Guangxi Key Laboratory of Polysaccharide Materials and Modification, Guangxi-Indonesia Joint Laboratory for Intelligent Mining of Microbial Resources, School of Marine Sciences and Biotechnology, Guangxi Minzu University, Nanning, Guangxi, China
    2.State Key Laboratory of Tropical Oceanography, Laboratory of Tropical Marine Bio-Resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, Guangdong, China
    3.University of Chinese Academy of Sciences, Beijing, China

Corresponding:

E-mail: JIANG Mingguo,
ZHANG Wenjun,
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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