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Genome mining and biosynthesis of microbial ribosomally synthesized and post-translationally modified peptides
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Kunling TENG1, Siyue WANG1, 2, Jiachen HU1, 2, Sijie JIN1, 2, Jin ZHONG1, 2
Acta Microbiologica Sinica | 2026, 66(5) : 2117 - 2132
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Acta Microbiologica Sinica | 2026, 66(5): 2117-2132
• Review •
Genome mining and biosynthesis of microbial ribosomally synthesized and post-translationally modified peptides
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Kunling TENG1, Siyue WANG1, 2, Jiachen HU1, 2, Sijie JIN1, 2, Jin ZHONG1, 2
Affiliations
  • 1.State Key Laboratory of Microbial Diversity and Innovative Utilization, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China
  • 2.University of Chinese Academy of Sciences, Beijing, China
Published: 2026-05-04 doi: 10.13343/j.cnki.wsxb.20250917
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Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a class of secondary metabolites synthesized by the ribosomes of microorganisms and formed through a series of post-translational modifications. They have diverse structures, high stability, and antimicrobial, antiviral, anti-inflammatory or anti-tumor activities. Moreover, they are not prone to generating drug resistance, thus showcasing great potential to be applied in the fields of medicine, food, and agriculture. The genomes of microorganisms harbor a large number of biosynthetic gene clusters for RiPPs, while many of them require the producing strains to be cultivated in specific conditions or to interact with other environmental microorganisms, being the “dark matter” in the genome. Heterologous biosynthesis is an effective means to obtain novel RiPPs and make use of them. This article reviews the recent research progress in the diversity, bioactivity, genomic mining, and heterologous biosynthesis of RiPPs from microorganisms, with the expectation of providing a theoretical basis for a deeper understanding of the molecular structures and functions of RiPPs, as well as for the development and application of novel microbial active metabolites and their producers.

ribosomally synthesized and post-translationally modified peptides  /  natural product  /  bioactivity  /  genome mining  /  heterologous biosynthesis
Kunling TENG, Siyue WANG, Jiachen HU, Sijie JIN, Jin ZHONG. Genome mining and biosynthesis of microbial ribosomally synthesized and post-translationally modified peptides[J]. Acta Microbiologica Sinica, 2026 , 66 (5) : 2117 -2132 . DOI: 10.13343/j.cnki.wsxb.20250917
Funding
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  • The National Key Research and Development Program of China(2021YFC2103900)
  • The International Partnership Program of Chinese Academy of Sciences(153211KYSB20210013)
Appendix
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Year 2026 volume 66 Issue 5
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Article Info
doi: 10.13343/j.cnki.wsxb.20250917
  • Receive Date：2025-12-09
  • Online Date：2026-05-09
  • Published：2026-05-04
Article Data
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History
  • Received：2025-12-09
  • Accepted：2026-01-15
Funding
The National Key Research and Development Program of China(2021YFC2103900)
The International Partnership Program of Chinese Academy of Sciences(153211KYSB20210013)
Affiliations
    1.State Key Laboratory of Microbial Diversity and Innovative Utilization, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China
    2.University of Chinese Academy of Sciences, Beijing, China

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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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