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Research progress in the biosynthesis and metabolic regulation of microbial-derived γ-aminobutyric acid
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Chenyue ZOU1, 2, Ying LI1, Shuxiang LIU2, Xin FAN1, Lanyan HUANG1, Moutong CHEN1
Acta Microbiologica Sinica | 2026, 66(5) : 2103 - 2116
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Acta Microbiologica Sinica | 2026, 66(5): 2103-2116
• Review •
Research progress in the biosynthesis and metabolic regulation of microbial-derived γ-aminobutyric acid
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Chenyue ZOU1, 2, Ying LI1, Shuxiang LIU2, Xin FAN1, Lanyan HUANG1, Moutong CHEN1
Affiliations
  • 1.State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Safety and Health, National Health Commission Science and Technology Innovation Platform for Nutrition and Safety of Microbial Food, Key Laboratory of Food Microbial Safety Big Data Technology (State Administration for Market Regulation), Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou, Guangdong, China
  • 2.College of Food Science, Sichuan Agricultural University, Ya’an, Sichuan, China
Published: 2026-05-04 doi: 10.13343/j.cnki.wsxb.20250849
Outline
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γ-Aminobutyric acid (GABA), a key inhibitory neurotransmitter in the central nervous system, plays a vital role in physiological functions such as promoting sleep, relieving tremors, and regulating blood pressure. Currently, a variety of microorganisms capable of synthesizing GABA have been identified, offering diverse strategic options for the biosynthesis of GABA through different metabolic pathways. This review provides a detailed summary of the major pathways—the GABA shunt pathway and the putrescine pathway—for GABA synthesis in various microorganisms. It systematically outlines the key synthases and metabolites involved in the two pathways, while comparing their synthesis efficiency and respective advantages. Furthermore, this study delves into the regulatory mechanisms underlying GABA biosynthesis in different microorganisms, along with key regulatory targets for enhancing synthesis efficiency. The work aims to establish a theoretical framework for the regulatory mechanisms of microbial-derived GABA synthesis and to provide a scientific basis for improving the efficiency of GABA biosynthesis.

γ-aminobutyric acid  /  microorganisms  /  biosynthetic genes  /  biosynthetic pathway  /  metabolic regulation
Chenyue ZOU, Ying LI, Shuxiang LIU, Xin FAN, Lanyan HUANG, Moutong CHEN. Research progress in the biosynthesis and metabolic regulation of microbial-derived γ-aminobutyric acid[J]. Acta Microbiologica Sinica, 2026 , 66 (5) : 2103 -2116 . DOI: 10.13343/j.cnki.wsxb.20250849
Funding
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  • The National Key Research and Development Program of China(2022YFD2100703)
  • The National Natural Science Foundation of China(32222068)
  • The Young Talents Special Project of Guangdong Academy of Sciences(2023GDASQNRC-0102)
Appendix
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Year 2026 volume 66 Issue 5
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151
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Article Info
doi: 10.13343/j.cnki.wsxb.20250849
  • Receive Date：2025-11-12
  • Online Date：2026-05-09
  • Published：2026-05-04
Article Data
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History
  • Received：2025-11-12
  • Accepted：2025-12-29
Funding
The National Key Research and Development Program of China(2022YFD2100703)
The National Natural Science Foundation of China(32222068)
The Young Talents Special Project of Guangdong Academy of Sciences(2023GDASQNRC-0102)
Affiliations
    1.State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Safety and Health, National Health Commission Science and Technology Innovation Platform for Nutrition and Safety of Microbial Food, Key Laboratory of Food Microbial Safety Big Data Technology (State Administration for Market Regulation), Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou, Guangdong, China
    2.College of Food Science, Sichuan Agricultural University, Ya’an, Sichuan, China

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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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