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Changes in Agap2 expression in hepatic fibrosis induced by hepatitis E virus infection
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Xiaoxia HU1, Yuanwen XUE1, Fen HUANG1, 2
Acta Microbiologica Sinica | 2026, 66(5) : 2404 - 2415
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Acta Microbiologica Sinica | 2026, 66(5): 2404-2415
• Research Article •
Changes in Agap2 expression in hepatic fibrosis induced by hepatitis E virus infection
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Xiaoxia HU1, Yuanwen XUE1, Fen HUANG1, 2
Affiliations
  • 1.Medical School, Kunming University of Science and Technology, Kunming, Yunnan, China
  • 2.Yunnan Provincial Key Laboratory of Clinical Virology, Kunming, Yunnan, China
Published: 2026-05-04 doi: 10.13343/j.cnki.wsxb.20250817
Outline
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Objective To investigate changes in ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 (Agap2) expression during hepatic fibrosis progression following hepatitis E virus (HEV) infection and preliminarily explore the association between chronic HEV infection and Agap2 expression. Methods A BALB/c mouse model of HEV infection was established through inoculation in tail vein and subjected to RNA sequencing. HEV infection and Agap2 expression in the liver tissue were detected via immunohistochemistry, immunofluorescence assay, and real-time qPCR. Results Agap2 expression was upregulated following HEV infection (24 hpi group: P=0.000 3, 48 hip group: P=0.001 9). Chronic HEV infection induced hepatic fibrosis in mice, and Agap2 expression in the mouse liver was positively correlated with HEV load (r=0.797 4, P<0.000 1). Similarly, in vitro experiments demonstrated that Agap2 expression was upregulated in HEV-infected Huh 7.5.1 cells (r=0.968 3, P=0.002 4) and LX-2 cells (r=0.683 5, P=0.006 5), showing a positive correlation with HEV load. Conclusion The results demonstrate that Agap2 expression is positively correlated with HEV load during hepatic fibrosis progression after chronic HEV infection. Agap2 may serve as a potential molecular target for the treatment of HEV-associated hepatic fibrosis.

hepatitis E virus (HEV)  /  ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 (Agap2)  /  hepatic fibrosis  /  alpha-smooth muscle actin (α-SMA)
Xiaoxia HU, Yuanwen XUE, Fen HUANG. Changes in Agap2 expression in hepatic fibrosis induced by hepatitis E virus infection[J]. Acta Microbiologica Sinica, 2026 , 66 (5) : 2404 -2415 . DOI: 10.13343/j.cnki.wsxb.20250817
Funding
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  • The Yunnan Provincial Natural Science Foundation(202401AS070057)
Appendix
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Year 2026 volume 66 Issue 5
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63
28
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Article Info
doi: 10.13343/j.cnki.wsxb.20250817
  • Receive Date：2025-10-31
  • Online Date：2026-05-09
  • Published：2026-05-04
Article Data
Affiliations
History
  • Received：2025-10-31
  • Accepted：2025-11-28
Funding
The Yunnan Provincial Natural Science Foundation(202401AS070057)
Affiliations
    1.Medical School, Kunming University of Science and Technology, Kunming, Yunnan, China
    2.Yunnan Provincial Key Laboratory of Clinical Virology, Kunming, Yunnan, China

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