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Research progress in the regulation of programmed cell death by gut microbiota in colorectal cancer
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Tiantian REN1, 2, 3, Min LIU2, 3, Qiangqiang TIAN1, 2, 3, Mi ZHAO1, 2, 3, Jianing JING1, 2, 3, Zhaofeng CHEN2, 3
Acta Microbiologica Sinica | 2026, 66(5) : 2048 - 2060
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Acta Microbiologica Sinica | 2026, 66(5): 2048-2060
• Review •
Research progress in the regulation of programmed cell death by gut microbiota in colorectal cancer
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Tiantian REN1, 2, 3, Min LIU2, 3, Qiangqiang TIAN1, 2, 3, Mi ZHAO1, 2, 3, Jianing JING1, 2, 3, Zhaofeng CHEN2, 3
Affiliations
  • 1.The First School of Clinical Medicine, Lanzhou University, Lanzhou, Gansu, China
  • 2.Department of Gastroenterology, the First Hospital of Lanzhou University, Lanzhou, Gansu, China
  • 3.Gansu Province Clinical Research Center for Digestive Diseases, the First Hospital of Lanzhou University, Lanzhou, Gansu, China
Published: 2026-05-04 doi: 10.13343/j.cnki.wsxb.20250886
Outline
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Colorectal cancer (CRC), one of the most common malignancies of the digestive system, is characterized by complex pathogenic mechanisms and an overall poor prognosis. The gut microbiota and its metabolites play a dual role in CRC by modulating various forms of programmed cell death (PCD), either promoting or inhibiting tumorigenesis and influencing the tumor responses to chemotherapy and immunotherapy. This review systematically summarizes recent advances in understanding how the gut microbiota regulates CRC initiation, progression, and responses to therapies through the modulation of apoptosis, autophagy, ferroptosis, and pyroptosis. Furthermore, it discusses the potential clinical-translational implications of these findings, aiming to provide a theoretical foundation for elucidating CRC pathogenesis and developing novel therapeutic strategies targeting the gut microbiota.

apoptosis  /  autophagy  /  colorectal cancer  /  gut microbiota
Tiantian REN, Min LIU, Qiangqiang TIAN, Mi ZHAO, Jianing JING, Zhaofeng CHEN. Research progress in the regulation of programmed cell death by gut microbiota in colorectal cancer[J]. Acta Microbiologica Sinica, 2026 , 66 (5) : 2048 -2060 . DOI: 10.13343/j.cnki.wsxb.20250886
Funding
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  • The Joint Scientific Research Fund of Gansu Province(24JRRA919)
  • The Gansu Province Research Program for Traditional Chinese Medicine(GZKZ-2024-22)
  • The Foundation of the First Hospital of Lanzhou University(ldyyyn2021-6)
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Year 2026 volume 66 Issue 5
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Article Info
doi: 10.13343/j.cnki.wsxb.20250886
  • Receive Date：2025-12-01
  • Online Date：2026-05-09
  • Published：2026-05-04
Article Data
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History
  • Received：2025-12-01
  • Accepted：2026-01-27
Funding
The Joint Scientific Research Fund of Gansu Province(24JRRA919)
The Gansu Province Research Program for Traditional Chinese Medicine(GZKZ-2024-22)
The Foundation of the First Hospital of Lanzhou University(ldyyyn2021-6)
Affiliations
    1.The First School of Clinical Medicine, Lanzhou University, Lanzhou, Gansu, China
    2.Department of Gastroenterology, the First Hospital of Lanzhou University, Lanzhou, Gansu, China
    3.Gansu Province Clinical Research Center for Digestive Diseases, the First Hospital of Lanzhou University, Lanzhou, Gansu, China

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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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