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Detection and functional regulation of the probiotic quorum sensing system
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Yiwen WANG1, Hao WU1, Danlei CHEN1, 2, Qinggele CAIYIN1, 2, Jianjun QIAO1, 2, Yanni LI1, Shengbo WU1, 2
Acta Microbiologica Sinica | 2026, 66(4) : 1600 - 1615
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Acta Microbiologica Sinica | 2026, 66(4): 1600-1615
• Review •
Detection and functional regulation of the probiotic quorum sensing system
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Yiwen WANG1, Hao WU1, Danlei CHEN1, 2, Qinggele CAIYIN1, 2, Jianjun QIAO1, 2, Yanni LI1, Shengbo WU1, 2
Affiliations
  • 1.State Key Laboratory of Synthetic Biology, Key Laboratory of Systems Bioengineering (Ministry of Education), School of Synthetic Biology and Biomanufacturing, Tianjin University, Tianjin, China
  • 2.Zhejiang Institute of Tianjin University, Shaoxing, Zhejiang, China
Published: 2026-04-04 doi: 10.13343/j.cnki.wsxb.20250984
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Quorum sensing (QS) is a communication mechanism through which microorganisms secrete and sense signal molecules to regulate mircobial population behaviors. QS plays important roles in biofilm formation and gut colonization of probiotics. In recent years, interfering with the QS of probiotics has become a trending research field of synthetic biology. In this review, we summarize the distribution of QS systems in probiotics and highlights interfering strategies designed to regulate probiotic functions. We summary currently identified QS systems in probiotics and their detection methods, such as photoelectrochemical assays and chromatography-mass spectrometry techniques. Meanwhile, this review outlines the QS interfering approaches for probiotics, including the use of QS agonists and the optimization of related metabolic pathways. Finally, the probiotic intervention strategy targeting QS is proposed in this paper, providing a novel approach for regulating the efficacy of engineered probiotics, which is of great significance for the development and improvement of probiotic functional foods.

probiotics  /  quorum sensing  /  detection technology  /  intervention strategy  /  synthetic biology
Yiwen WANG, Hao WU, Danlei CHEN, Qinggele CAIYIN, Jianjun QIAO, Yanni LI, Shengbo WU. Detection and functional regulation of the probiotic quorum sensing system[J]. Acta Microbiologica Sinica, 2026 , 66 (4) : 1600 -1615 . DOI: 10.13343/j.cnki.wsxb.20250984
Funding
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  • “Pioneer” and “Leading Goose” Research and Development Program of Zhejiang Province(2025C01102)
  • National Natural Science Foundation of China(32300022)
Appendix
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Year 2026 volume 66 Issue 4
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136
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Article Info
doi: 10.13343/j.cnki.wsxb.20250984
  • Receive Date：2025-12-28
  • Online Date：2026-04-14
  • Published：2026-04-04
Article Data
Affiliations
History
  • Received：2025-12-28
  • Accepted：2026-02-04
Funding
“Pioneer” and “Leading Goose” Research and Development Program of Zhejiang Province(2025C01102)
National Natural Science Foundation of China(32300022)
Affiliations
    1.State Key Laboratory of Synthetic Biology, Key Laboratory of Systems Bioengineering (Ministry of Education), School of Synthetic Biology and Biomanufacturing, Tianjin University, Tianjin, China
    2.Zhejiang Institute of Tianjin University, Shaoxing, Zhejiang, China

Corresponding:

E-mail: LI Yanni,
WU Shengbo,
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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